ArticleJournal of biomedical optics2026
Label-free wide-field imaging of brain tumors using near-infrared endogenous fluorescence and reflectance normalization.
Article in Journal of biomedical optics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Significance: Maximizing safe tumor resection remains a major challenge in brain tumor surgery due to the lack of reliable real-time intraoperative contrast between tumor and healthy brain tissue. Label-free optical methods based on endogenous tissue fluorescence could provide simple, noninvasive feedback to guide resection while avoiding the logistical and regulatory limitations of exogenous fluorophores. Aim: The study aims to investigate whether endogenous near-infrared (NIR) fluorescence can differentiate tumor from normal brain tissue Approach: We analyzed Results: Endogenous fluorescence intensity measured Conclusions: Endogenous NIR fluorescence provides intrinsic contrast between normal and tumoral brain tissue. The demonstrated corrected wide-field fluorescence imaging approach could offer a feasible, label-free method for real-time visualization of tumor margins, supporting its future clinical translation as an intraoperative guidance tool.
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