Evidence map›Paper›PMID 42592192›Full record

ArticleActa pharmaceutica Sinica. B2026

Loss of TET2 sulfhydration results in destabilization of TET2 and down-regulation of the immune response in melanoma.

Di Wang, Weiwei Deng, Yang Xie, Ansheng Xie, Yuan Chang, Shuheng Li, Yishan Chen, Leiqiong Gao, Yan Zhang, Zhiying Yu and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmaceutica Sinica. B, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

17 authors.

Di WangDermatology Hospital of Southern Medical University, Guangzhou 510091, China.
Weiwei DengDermatology Hospital of Southern Medical University, Guangzhou 510091, China.
Yang XieDepartment of Dermatology, The 3rd Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Ansheng XieHunan Key Laboratory of Medical Epigenomics & Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha 410011, China.
Yuan ChangDepartment of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Shuheng LiDermatology Hospital of Southern Medical University, Guangzhou 510091, China.
Yishan ChenDermatology Hospital of Southern Medical University, Guangzhou 510091, China.
Leiqiong GaoInstitute of Immunological Innovation and Translation, Chongqing Medical University, Chongqing 400016, China.
Yan ZhangDermatology Hospital of Southern Medical University, Guangzhou 510091, China.
Zhiying YuDermatology Hospital of Southern Medical University, Guangzhou 510091, China.
Bocheng WangDermatology Hospital of Southern Medical University, Guangzhou 510091, China.
Yingping XuDermatology Hospital of Southern Medical University, Guangzhou 510091, China.
Haijing WuHunan Key Laboratory of Medical Epigenomics & Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha 410011, China.
Yan DingDepartment of Dermatology, Hainan Provincial Hospital of Skin Disease, Haikou 570206, China.
Bin YangDermatology Hospital of Southern Medical University, Guangzhou 510091, China.
Lian ZhangDermatology Hospital of Southern Medical University, Guangzhou 510091, China.
Yunsheng LiangHunan Key Laboratory of Medical Epigenomics & Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha 410011, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Loss of TET2 protein leads to reduced DNA 5-hydroxymethylation (5-hmC), a key epigenetic alteration in melanoma, yet the regulatory mechanism governing TET2 stability remains unclear. Here, TET2 sulfhydration was analyzed in clinical melanoma samples, with sulfhydration sites identified by mass spectrometry, and the effects of active sulfur on TET2 stability, catalytic activity, and global 5-hmC assessed in melanoma cells. TET2 sulfhydration was significantly depleted in melanoma and further reduced in advanced stages. The cysteine-rich zinc finger domain at C1186/1202 was identified as the key sulfhydration site, which is essential for maintaining TET2 stability and enzymatic activity. Active sulfur restored TET2 sulfhydration, up-regulated TET2 protein, and reprogrammed global DNA hydroxymethylation. Notably, active sulfur synergized with anti-PD-1 therapy by enhancing IFN-

Indexed as

Active sulfurDNA hydroxymethylationEpigeneticsImmunotherapyMelanomaPD-1S-sulfhydrationTET2 protein

Identifiers

PMID42592192
PMCPMC13464072

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.