Evidence map›Paper›PMID 42592160›Full record

ReviewFrontiers in immunology2026

Cole W Christopher, Xiaoyu Zhou

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Cole W ChristopherVaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, United States.
Xiaoyu ZhouVaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, United States.

Funding

Reprogramming T cell function with multiplexed genome engineering to develop next-generation immunotherapyR00CA282989 · NCI · WISTAR INSTITUTE · PI XIAOYU ZHOU · 2025 to 2026
$498k
NCI NIH HHS R00 CA282989
6 · The paper itself

Abstract

Cancer immunotherapy has shown significant promise in certain patient populations, but further advancements are needed to extend its benefits to a wider range of patients. Clustered regularly interspaced short palindromic repeats (CRISPR)-based editing has rapidly evolved in recent years, enabling its transition into direct therapeutic applications. This review summarizes recent progress in applying CRISPR systems

Indexed as

CRISPR-Cas SystemsGene EditingGenetic TherapyImmunotherapyNeoplasmsAnimalsHumansTumor Microenvironmentcancercell therapyCRISPRgene editinggene therapyimmunotherapyt cellstumor microenvironment

Identifiers

PMID42592160
PMCPMC13463192

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.