Evidence map›Paper›PMID 42592147›Full record

ArticleJournal of the American Statistical Association2026

Investigating Spatial Dynamics in Spatial Omics Data with StarTrail.

Jiawen Chen, Caiwei Xiong, Quan Sun, Yutong Song, Geoffery W Wang, Gaorav P Gupta, Aritra Halder, Yun Li, Didong Li

Abstract read
In one paragraph

Article in Journal of the American Statistical Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jiawen ChenDepartment of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, NC.
Caiwei XiongDepartment of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, NC.
Quan SunCenter for Computational and Genomic Medicine, Children's Hospital of Philadelphia, Philadelphia, PA.ORCID 0000-0001-8324-2803
Yutong SongDepartment of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, NC.
Geoffery W WangDepartment of Statistics and Operations Research, The University of North Carolina at Chapel Hill, Chapel Hill, NC.
Gaorav P GuptaDepartment of Radiation Oncology, The University of North Carolina at Chapel Hill, Chapel Hill, NC.
Aritra HalderDepartment of Epidemiology and Biostatistics, Drexel University, Philadelphia, PA.
Yun LiDepartment of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, NC.
Didong LiDepartment of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, NC.

Funding

Tissue Procurement & PathologyP50CA058223 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BENJAMIN CARLISLE CALHOUN · 1992 to 2026
$59.3M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3M
The UNC Chapel Hill Superfund Research Program (UNC-SRP)P42ES031007 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Kathleen M Gray · 2020 to 2026
$22.2M
Preclinical CoreP50HD103573 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GABRIEL S DICHTER · 2020 to 2026
$9.7M
Study of Selective Cell and System Vulnerability in Alzheimer's DiseaseR01AG079291 · NIA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Li Gan, Yun Li · 2023 to 2026
$5.4M
Polygenic risk scores for cardiometabolic disorders: the role of blood cells immune response and evolutionary adaptationU01HG011720 · NHGRI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Yun Li, ALEXANDER P REINER · 2021 to 2026
$5.4M
Robust Computational and Data Analytic Tools for In-depth Understanding Postoperative Pain Mechanism with Enhanced Pain Management and Clinical Decision MakingR01LM014407 · NLM · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Baiming Zou · 2024 to 2026
$1.4M
NCI NIH HHS P50 CA058223NHGRI NIH HHS U01 HG011720NIA NIH HHS R01 AG079291NICHD NIH HHS P50 HD103573NIEHS NIH HHS P30 ES010126NIEHS NIH HHS P42 ES031007NLM NIH HHS R01 LM014407
6 · The paper itself

Abstract

Spatial omics technologies revolutionize our view of biological processes within tissues. However, existing methods fail to capture localized, sharp changes characteristic of critical events (e.g., tumor development). Here, we present StarTrail, a novel gradient based method that powerfully defines rapidly changing regions and detects "cliff genes", genes exhibiting drastic expression changes at highly localized or disjoint boundaries. StarTrail, the first to leverage spatial gradients for spatial omics data, also quantifies

Indexed as

Boundary detectionCliff geneGaussian Processgradients

Identifiers

PMID42592147
PMCPMC13464541

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.