ArticleInternational journal of dentistry2026
Effects of Zoledronate on Alveolar Bone and Teeth in Rats: Relationship Between Root Resorption and Occlusion.
Article in International journal of dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Effects of Zoledronate on Alveolar Bone and Teeth in Rats: Relationship Between Root Resorption and Occlusion.International journal of dentistry · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Bisphosphonates (BPs) are used to treat osteoporosis and other bone metabolic diseases. Zoledronate (ZOL), a third-generation BP, induces osteoclast apoptosis and inhibits bone resorption. Previous studies have mainly focused on limb bones, and few studies have reported the effects of ZOL administration alone in the oral region. The objective of this study was to investigate the effects of ZOL on teeth and alveolar bone. Methods: Wistar rats were injected intraperitoneally with 40 or 400 μg/kg ZOL, and the right mandibular first molar of some rats were extracted. The rats were euthanized 3 weeks postoperatively. The tibia and maxilla were analyzed histopathologically using hematoxylin and eosin (HE) or tartrate-resistant acid phosphatase (TRAP) staining. Results: In the 40 and 400 μg/kg ZOL groups, dense trabecular bone tissues were observed in the tibia. Osteoclasts in the tibia and alveolar bone were enlarged and had numerous nuclei, and many osteoclasts were detached from the bone surface. These changes were more evident in the 400 μg/kg ZOL group. Root resorption in the maxillary first molar was observed in the apical dentin, and the odontoclasts within the resorption cavities were TRAP-positive. In an experiment with tooth extraction, the nonocclusal side of the maxilla exhibited significantly fewer root resorption cavities than the occlusal side in both 40 and 400 μg/kg ZOL groups. Conclusions: These findings demonstrate that ZOL administration induces irregularities in the alveolar bone surface and root resorption in a dose-dependent manner. They also suggest a correlation between occlusal status and the extent of root resorption in ZOL-treated rats.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.