Evidence map›Paper›PMID 42592100›Full record

ArticleInternational journal of pharmaceutics: X2026

A ROS‑responsive liposome for atherosclerosis treatment via combined regulation of lipid metabolism and CD47 blockade.

Peng Yuan, Shibo Tian, Chao Cui, Chenglu Sun, Chuang Tang, Dengfeng Gao, Lu Lu, Keren Long, Funeng Xu, Gang Shu and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of pharmaceutics: X, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Peng YuanState Key Laboratory of Swine and Poultry Breeding Industry, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.
Shibo TianState Key Laboratory of Swine and Poultry Breeding Industry, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.
Chao CuiState Key Laboratory of Swine and Poultry Breeding Industry, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.
Chenglu SunState Key Laboratory of Swine and Poultry Breeding Industry, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.
Chuang TangLivestock and Poultry Multi-omics Key Laboratory of Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Dengfeng GaoLivestock and Poultry Multi-omics Key Laboratory of Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Lu LuLivestock and Poultry Multi-omics Key Laboratory of Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Keren LongLivestock and Poultry Multi-omics Key Laboratory of Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Funeng XuCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.
Gang ShuCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.
Wei ZhangCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.
Xiaoxia LiangCollege of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.
Fanli KongState Key Laboratory of Swine and Poultry Breeding Industry, College of Life Science, Sichuan Agricultural University, Chengdu 611130, China.
Mingzhou LiLivestock and Poultry Multi-omics Key Laboratory of Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.
Haohuan LiState Key Laboratory of Swine and Poultry Breeding Industry, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atherosclerosis is one of the leading causes of death worldwide. Excessive lipid accumulation and defective efferocytosis trigger massive foam cell formation, which serves as a key driver of atherosclerotic plaque progression. In this work, we developed a phospholipid-based nanocarrier (Ato@LHP) to co-load atorvastatin and a CD47-blocking peptide. This system achieves targeted treatment of atherosclerosis through lipid removal and dual CD47 blockade. We used RAW264.7 cells to build foam cell models

Indexed as

AtherosclerosisCD47 dual blockadeFoam cellsLipid clearance

Identifiers

PMID42592100
PMCPMC13463256

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.