ReviewTranslational pediatrics2026
Participation of children with obstructive sleep apnea in clinical trials: a systematic review of barriers and interventions.
Review in Translational pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Obstructive sleep apnea (OSA) has negative effects on neurocognitive development and metabolic health in children. Despite this, children with OSA remain underrepresented in research; consequently, most evidence on treatment is based on adult data. This review focuses on studies assessing barriers to clinical trial participation in children with OSA and discusses intervention studies and efforts to overcome these barriers. Methods: We retrieved articles from Scopus, Embase, PubMed, and the Cochrane Library without date restrictions until February 2026. The language used was restricted to English. The Joanna Briggs Institute (JBI) tool was used to assess methodological quality. Results: Of the 28 included studies, 14 barrier subcategories were identified across three domains: objective factors (25 studies), provider factors (6 studies), and patient/caregiver factors (25 studies). The most frequently reported barriers were stringent eligibility criteria, refusal of follow-up, treatment disagreement, and health problem. Conclusions: Our findings emphasize multifaceted barriers to enrolling children with OSA in clinical trials. Furthermore, we provided several underutilized solutions to facilitate children's participation in clinical trials. However, formal targeted strategies are still needed in the future, because these recommendations alone might not solve the evidence gap in children.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.