Evidence map›Paper›PMID 42591907›Full record

ReviewFrontiers in immunology2026

Atopic dermatitis: pathogenesis, immunology, microbiome, and salivary biomarkers.

Simona Abraityte, Laura Tamasauskiene, Edita Gasiuniene, Lina Jankauskaite

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Simona AbraityteDepartment of Pediatrics, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Laura TamasauskieneDepartment of Immunology and Allergology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Edita GasiunieneDepartment of Immunology and Allergology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Lina JankauskaiteDepartment of Pediatrics, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atopic dermatitis is a chronic inflammatory skin disease influenced by genetic predisposition, immune dysregulation, and environmental factors, as well as skin and gut microbiota. This review summarises the key mechanisms involved in this disease development, including disturbances in innate and adaptive immune responses, ethnic differences in immune pathways, and the contribution of microbial imbalance to skin barrier dysfunction. Special attention is given to salivary biomarkers-such as cortisol, melatonin, alpha-amylase, chromogranin A, C-reactive protein, and immunoglobulin A-which offer a non-invasive method for monitoring stress, sleep quality, and disease severity in patients with atopic dermatitis. Understanding the complexity of these factors may support earlier diagnosis and different treatment strategies and improve long-term disease management in a better way.

Indexed as

Dermatitis, AtopicMicrobiotaSalivaAnimalsBiomarkersHumansImmunity, InnateSkinSkin MicrobiomeBiomarkersatopic dermatitisgut-skin axisimmune systemsalivary biomarkersskin inflammationskin microbiome

Identifiers

PMID42591907
PMCPMC13462598

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.