ArticleTranslational cancer research2026
Garcinoic acid promotes ferroptosis-associated growth inhibition in esophageal squamous cell carcinoma through an MDM2-associated mechanism.
Article in Translational cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Garcinoic acid (GA), a plant metabolite, has been shown to exhibit anti-inflammatory and antioxidant activities; however, its mechanism of action against esophageal squamous cell carcinoma (ESCC) remains unclear. This study aimed to investigate the effects of GA on ESCC and to elucidate its underlying molecular mechanisms. Methods: The anti-ESCC effects of GA were evaluated using cell counting kit-8 (CCK-8) assays, 5-ethynyl-2'-deoxyuridine (EdU) staining, acridine orange/ethidium bromide (AO/EB) staining, and Transwell assays. Ferroptosis-associated changes were assessed using C11-BODIPY staining, reactive oxygen species (ROS), Fe Results: GA inhibited ESCC cell proliferation, induced apoptosis, and reduced cell migration. GA increased levels of MDA and Fe Conclusions: These findings suggest that GA induces ferroptosis-associated growth inhibition in ESCC cells, potentially through an MDM2-associated mechanism, and provide a rationale for further investigation of GA-related ferroptosis modulation in ESCC.
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