ArticleFrontiers in medicine2026
Predictive value of combined electrocardiographic and echocardiographic parameters for major adverse cardiovascular events in patients with established coronary artery disease: a single-center retrospective cohort study.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To explore the predictive value of combining conventional ECG parameters (P-wave dispersion, Sokolow-Lyon voltage) and echocardiographic parameters (left atrial volume index, LAVI) for major adverse cardiovascular events (MACE) in coronary artery disease (CAD) patients. Methods: From January 2024 to February 2026, 306 angiographically confirmed CAD patients were enrolled. All underwent standard 12-lead ECG and transthoracic echocardiography at admission. Over a median follow-up of 15.2 months, 50 patients developed MACE and 256 remained event-free. Baseline ECG (P-wave dispersion, QTc, Sokolow-Lyon voltage) and echocardiographic parameters (LAVI, left ventricular ejection fraction, left ventricular mass index) were compared. Independent predictors were identified by multivariate Cox regression, and a combined model was built. Incremental value was assessed by C-index, net reclassification improvement (NRI), and integrated discrimination improvement (IDI). The study was approved by the institutional review board. Results: The MACE group had higher P-wave dispersion, LAVI, and left ventricular mass index, and lower Sokolow-Lyon voltage and LVEF (all Conclusion: Routinely available ECG-derived P-wave dispersion and echocardiographic LAVI are independent, complementary predictors of MACE in CAD patients. Integrating these two parameters into a simple risk model significantly enhances risk discrimination and reclassification, providing a practical, cost-effective tool for individualized management.
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