Evidence map›Paper›PMID 42591819›Full record

ArticleGland surgery2026

A randomized controlled trial: application of inactivated

Mingda Zhao, Tianming Fang, Haonan Jiang, Jianyi Li

Registry-linked trialAbstract read
In one paragraph

Article in Gland surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07460297 (Pseudomonas Aeruginosa Injection Combined With Polyvinylpyrrolidone-Iodine in Immediate Breast Reconstruction Surgery With Implants:a Randomized Controlled Trial), which is not on this map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07460297 naenrolling by invitationnot on this map

Pseudomonas Aeruginosa Injection Combined With Polyvinylpyrrolidone-Iodine in Immediate Breast Reconstruction Surgery With Implants:a Randomized Controlled Trial

TypeinterventionalSponsorJianyi LiRan2025 to 2028Enrolled100ConditionsPostoperative Seroma Rate, Drainage Tube Removal Time, and Capsular Contracture Rate, Seroma Following ProcedureArmsPseudomonas aeruginosa, Povidone-Iodine
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mingda ZhaoDepartment of Breast Surgery, Liaoning Cancer Hospital & The Cancer Hospital of Dalian University of Technology, Shenyang, China.ORCID https://orcid.org/0009-0001-2116-9222
Tianming FangDepartment of Breast Surgery, Liaoning Cancer Hospital & The Cancer Hospital of Dalian University of Technology, Shenyang, China.
Haonan JiangDepartment of Breast Surgery, Liaoning Cancer Hospital & The Cancer Hospital of Dalian University of Technology, Shenyang, China.
Jianyi LiDepartment of Breast Surgery, Liaoning Cancer Hospital & The Cancer Hospital of Dalian University of Technology, Shenyang, China.ORCID https://orcid.org/0000-0002-0556-9111

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Breast cancer is one of the most commonly diagnosed malignancies worldwide. For patients undergoing nipple-sparing mastectomy with immediate prosthetic reconstruction (NSM-IPR), optimizing postoperative recovery and reducing complications are critical. Prolonged postoperative drainage is a common issue that increases infection risk and prolongs hospital stay. This study aimed to evaluate the effect of an inactivated Methods: This was a single-center, prospective, four-arm parallel-group randomized controlled trial. A total of 100 patients were randomly assigned in a 1:1:1:1 ratio to receive either low-, medium-, or high-concentration inactivated PAP immersion, or povidone-iodine alone (control). Outcome assessors were blinded. Therapeutic efficacy was assessed, including total drainage volume, drainage duration, complications, and cosmetic outcomes at 3 months postoperatively. Results: Total drainage volume was significantly lower in all PAP groups compared with the control group (low-concentration: 578.4±39.34 mL, medium-concentration: 477.8±35.53 mL, high-concentration: 444.8±34.26 mL Conclusions: The combination of inactivated PAP and povidone-iodine reduces postoperative drainage volume, shortens drainage time, and may improve cosmetic outcomes in patients undergoing NSM-IPR. Trial Registration: ClinicalTrials.gov NCT07460297.

Indexed as

Breast cancerdrainageimmediate prosthetic reconstruction (IPR)nipple-sparing mastectomy (NSM)Pseudomonas aeruginosa preparation (PAP)

Identifiers

PMID42591819
PMCPMC13462853

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Registered trials

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