Evidence map›Paper›PMID 42591693›Full record

ArticleFrontiers in antibiotics2026

Carbapenem resistance genes and biofilm-virulence uncoupling in

Shyam Tripathi, Kusum Rani, Rivan Berlia, Amit Sharma, Anandu Hari, Pratibha Gaur, Poornima Sheba Samuel Raj, V Samuel Raj

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In one paragraph

Article in Frontiers in antibiotics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shyam TripathiDepartment of Biotechnology and Microbiology, School of Science and Humanities, SRM University, Sonepat, Haryana, India.
Kusum RaniCentre for Drug Design Discovery and Development (C4D), SRM University, Sonepat, Haryana, India.
Rivan BerliaCentre for Drug Design Discovery and Development (C4D), SRM University, Sonepat, Haryana, India.
Amit SharmaDepartment of Biotechnology and Microbiology, School of Science and Humanities, SRM University, Sonepat, Haryana, India.
Anandu HariDepartment of Infection Prevention and Epidemiology, Amrita School of Medicine, Amrita Vishwa Vidyapeetham, Faridabad, Haryana, India.
Pratibha GaurDepartment of Biotechnology and Microbiology, School of Science and Humanities, SRM University, Sonepat, Haryana, India.
Poornima Sheba Samuel RajPRIMSR Hospital, SRM University, Sonipat, Haryana, India.
V Samuel RajDepartment of Biotechnology and Microbiology, School of Science and Humanities, SRM University, Sonepat, Haryana, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Methods: A total of 200 non-duplicate Results: Among 200 isolates, 54% were MDR, 34% XDR, and 61% carbapenem-resistant. The blaOXA-23 gene, present in 61%, showed near-perfect concordance with carbapenem resistance (κ = 0.81). Composite carbapenemase carriage improved concordance (κ = 0.88). Biofilm capacity was unrelated to overall resistance, but strong biofilm formers had higher colistin MICs (p = 0.001). Virulence genes ( Conclusions: blaOXA-23 emerged as the dominant genetic driver of carbapenem resistance, underscoring its value in rapid diagnostics. Colistin tolerance was linked to biofilm-associated phenotypes rather than cumulative resistance.

Indexed as

Acinetobacter baumanniibiofilmblaOXA-23carbapenem resistancegenotype-phenotype concordancevirulence genes

Identifiers

PMID42591693
PMCPMC13462743

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.