Ectopic ACTH-dependent Cushing syndrome in 3 hospitalized patients: lessons learned from management with osilodrostat.

Hannah Ruggles, Emmy Yang, Nikita Mohan, Luis Borges Espinosa, Elizabeth Harris, Morgan Jones

Abstract readCase Reports

In one paragraph

Article in JCEM case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hannah RugglesDivision of Endocrinology and Metabolism, Department of Internal Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.ORCID https://orcid.org/0009-0000-5020-8262

Emmy YangDivision of Geriatric Medicine, Department of Internal Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.ORCID https://orcid.org/0000-0001-8966-9971

Nikita MohanDivision of Endocrinology and Metabolism, Department of Internal Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.ORCID https://orcid.org/0000-0003-1966-8150

Luis Borges EspinosaDivision of Endocrinology and Metabolism, Department of Internal Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.ORCID https://orcid.org/0009-0002-7245-1639

Elizabeth HarrisDivision of Endocrinology and Metabolism, Department of Internal Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.ORCID https://orcid.org/0009-0003-9836-4426

Morgan JonesDivision of Endocrinology and Metabolism, Department of Internal Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.ORCID https://orcid.org/0000-0002-8503-7309

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe Cushing syndrome (CS) is a rare diagnosis with high mortality, which limits the ability of endocrinologists to gain experience delivering care. Here we describe our experience treating 3 cases of ectopic ACTH-dependent CS presenting in a single year. The initial diagnosis of each case was made during hospitalization resulting from complications of CS, implicating severe disease and delayed diagnosis. Our experience suggests that rapid initiation and titration of osilodrostat effectively treats hypercortisolism and improves outcomes.

Indexed as

ectopic ACTH-dependent Cushing syndromehypercortisolismosilodrostat

Identifiers

PMID42591670

DOI10.1210/jcemcr/luag213

PMCPMC13462791

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.