ArticleTranslational cancer research2026
Elevated TMC8 expression correlates with CD8
Article in Translational cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Background: Oral squamous cell carcinoma (OSCC) outcomes are fundamentally dictated by complex interactions within the tumor immune microenvironment. Elevated expression of transmembrane channel-like 8 (TMC8) has been correlated with favorable survival across various solid tumors. However, it remains undetermined whether this prognostic benefit reflects a tumor-suppressive cellular function or a broader microenvironmental crosstalk. This study aimed to investigate the cell-autonomous role of TMC8 in OSCC and explore its broader immunological crosstalk within the tumor microenvironment (TME). Methods: The present study integrated large-scale immunogenomic analyses of 315 clinical samples with Results: While TMC8 was significantly upregulated in malignant tissues, elevated expression strongly predicted prolonged overall and progression-free survival. Conclusions: The intrinsic cellular pro-tumorigenic role of TMC8 might be counterbalanced by its potential association with danger-sensing networks. This potential network association could be linked to a multicellular inflammatory crosstalk that correlates with cytotoxic T lymphocyte recruitment, providing a plausible hypothesis for the paradoxical survival benefit and highlighting its value as a prognostic biomarker.
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