Evidence map›Paper›PMID 42591649›Full record

ArticleClinical Medicine Insights. Oncology2026

Shunsuke Imamura, Takeshi Uehara, Mai Iwaya, Shiho Asaka, Shinsuke Sugenoya, Hiroshi Sawaguchi, Takahiro Yoshizawa, Yasuhiro Kuraishi, Tomoyuki Nakajima, Shotaro Komamura and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical Medicine Insights. Oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Shunsuke ImamuraDivision of Gastroenterology and Hepatology, Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan.ORCID https://orcid.org/0009-0000-7074-4011
Takeshi UeharaDepartment of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Japan.ORCID https://orcid.org/0000-0002-7694-9015
Mai IwayaDepartment of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
Shiho AsakaDepartment of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
Shinsuke SugenoyaDivision of Gastroenterological, Hepato-Biliary-Pancreatic, Transplantation and Pediatric Surgery, Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
Hiroshi SawaguchiDivision of Gastroenterology and Hepatology, Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan.ORCID https://orcid.org/0009-0003-7271-3106
Takahiro YoshizawaDivision of Gastroenterological, Hepato-Biliary-Pancreatic, Transplantation and Pediatric Surgery, Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
Yasuhiro KuraishiDivision of Gastroenterology and Hepatology, Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
Tomoyuki NakajimaDepartment of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
Shotaro KomamuraDepartment of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
Akira NakamuraDivision of Gastroenterology and Hepatology, Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
Yugo IwayaDivision of Gastroenterology and Hepatology, Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
Akira ShimizuDivision of Gastroenterological, Hepato-Biliary-Pancreatic, Transplantation and Pediatric Surgery, Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
Yuji SoejimaDivision of Gastroenterological, Hepato-Biliary-Pancreatic, Transplantation and Pediatric Surgery, Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
Hiroyoshi OtaDepartment of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
Tadanobu NagayaDivision of Gastroenterology and Hepatology, Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The clinical significance of CXC ligand 12 (CXCL12) expression at the invasive front of pancreatic ductal adenocarcinoma (PDAC) remains unclear. This study examined the expression of stromal Methods: This retrospective investigation analyzed Results: CXCL12-positive staining was found in 88% of samples, with expression predominantly in the stroma rather than in tumor cells. Venous invasion was significantly less in the high Conclusion: RNAscope findings revealed that stromal

Indexed as

CXCL12pancreatic cancerRNA in situ hybridizationscRNA-seqtumor microenvironment

Identifiers

PMID42591649
PMCPMC13462501

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.