Evidence map›Paper›PMID 42591600›Full record

SynthesisFrontiers in oral health2026

Association between smoking cessation and periodontitis progression: a systematic review and meta-analysis of prospective observational studies.

Yangyang Xie, Ya Ma, Zhen Geng, Hongfan Zhao, Xiaonan Li, Liwen Wang, Peijing Yan, Xiliang Jiang, Min Zhang

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yangyang XieSchool of Stomatology, Southern Medical University, Guangzhou, Guangdong, China.
Ya MaThe First Clinical Medical College of Gansu University of Chinese Medicine (Gansu Provincial Hospital), Lanzhou, Gansu, China.
Zhen GengDepartment of Science and Technology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Hongfan ZhaoFirst Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
Xiaonan LiFirst Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
Liwen WangFirst Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
Peijing YanClinical Research Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Xiliang JiangDepartment of Stomatology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
Min ZhangClinical Research Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: This systematic review and meta-analysis aimed to investigate the association between smoking cessation and periodontitis progression by comparing periodontal outcomes in patients who quit smoking vs. those who continued smoking. Methods: PubMed, Embase, and the Cochrane Library were searched for prospective studies (published up to March 2025) on smoking cessation and periodontitis progression, with ≥3 months' follow-up. The primary outcome was probing depth. R Studio 4.1.3 was used for random-effects meta-analyses, sensitivity, and subgroup analyses. Results: Six studies ( Conclusion: Smoking cessation may be associated with modest short-term improvements in periodontal parameters, particularly PD and CAL. However, further high-quality studies with longer follow-up are warranted to confirm clinical relevance.

Indexed as

meta-analysisperiodontitisperiodontitis progressionprospective observational studysmoking cessation

Identifiers

PMID42591600
PMCPMC13461921

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.