ArticleFrontiers in public health2026
Development and validation of the childhood allergy comprehensive screening questionnaire and Its application in a cross-sectional survey of allergic diseases among children aged 0-6 Years in Shanghai, China.
Article in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Childhood allergic diseases constitute a substantial global health burden, with children aged 0-6 years representing a highly vulnerable population during early immunological transition. Evidence regarding the associations of lifestyle, household environments, and prenatal exposures with these conditions remains inconsistent and heterogeneous, and epidemiological data for this critical age group are still limited. This study aimed to develop and validate a standardized screening instrument and to evaluate these potential associations. Methods: This study utilized a two-phase design: Phase I (Clinical Validation) evaluated the psychometric properties of a newly developed, culturally localized 24-item Childhood Allergy and Asthma Comprehensive Screening Questionnaire (CACSQ) against clinical gold-standard physician diagnoses in a hospital-based case-control study comprising 98 cases and 98 matched controls. Phase II (Epidemiological Survey) applied the validated CACSQ in a district-wide cross-sectional investigation. Using multi-stage stratified random cluster sampling, 3,064 children aged 0-6 years were enrolled in Minhang District, Shanghai, China. Multivariable logistic regression models were employed to identify independent perinatal, residential-environmental, and familial factors associated with childhood allergies. Results: The CACSQ demonstrated high accuracy, with an AUC of 0.88 ( Conclusion: Genetic predisposition and modifiable environmental/lifestyle factors significantly associated with early childhood allergies. The validated CACSQ offers a reliable, low-cost screening tool for early detection and future longitudinal cohort studies.
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