ReviewLaryngoscope investigative otolaryngology2026
Drug-Induced Sleep Endoscopy in Infants With Obstructive Sleep Apnea: Current Evidence and Knowledge Gaps.
Review in Laryngoscope investigative otolaryngology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To map and synthesize the available evidence and evidence gaps on drug-induced sleep endoscopy (DISE) in infants with obstructive sleep apnea (OSA), focusing on reported sites of obstruction, DISE-associated management decisions, postoperative outcomes, safety, and limitations in current reporting. Data Sources: PubMed/MEDLINE/Embase/Google Scholar was searched for studies published in English and French from January 1980 to September 2025. Review Methods: This scoping review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines. Eligible studies included original reports describing infants under 12 months with OSA who underwent DISE. Two reviewers independently screened titles, abstracts, and full texts, extracted data with a standardized form, and synthesized results descriptively. Extracted variables included available polysomnography (PSG) parameters, DISE methodology, comparator airway evaluations when reported, DISE-directed interventions, postoperative outcomes, and complications. Results: Eight observational studies published between 2013 and 2024 met inclusion criteria, involving 151 infants. DISE often revealed multilevel obstruction, most commonly involving the supraglottis (epiglottis, aryepiglottic folds, arytenoids; including sleep-state laryngomalacia) and retrolingual airway. Contributors from the nasal and adenotonsillar regions were also reported. DISE findings were associated with variable interventions, most frequently supraglottoplasty and adenoidectomy/tonsillectomy, with selected cases requiring mandibular distraction, tongue-lip adhesion, or tracheostomy. When postoperative PSG was available, indices generally improved (mean apnea-hypopnea index [AHI] approximately 10.6 events/h preoperatively and 3 events/h postoperatively). No major DISE-related complications were consistently described. Conclusion: In infants with OSA, DISE appears feasible and may identify dynamic, often multilevel obstruction, particularly supraglottic and retrolingual collapse. However, current evidence remains limited by small retrospective series, inconsistent PSG reporting, variable DISE protocols, and limited objective postoperative outcomes. Prospective studies with standardized DISE methods, uniform PSG reporting, defined outcome measures, and comparator airway evaluations are needed. Level of Evidence: 2.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.