ArticleTranslational cancer research2026
Bergamottin demonstrates preclinical effectiveness against pancreatic cancer by modulating PPAR-γ to induce apoptosis.
Article in Translational cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Pancreatic cancer (PC) has escalating incidence and mortality rates, with poor prognosis and resistance to traditional therapies, highlighting the urgent need for new drug development. Bergamottin, a natural furanocoumarin from bergamot oil, has diverse biological activities, but its anticancer effects on PC remain scarce and limited. This study aimed to investigate the anticancer properties of bergamottin in PC and elucidate the regulatory mechanism of PPAR-γ in inducing apoptosis. Methods: Results: Bergamottin significantly inhibited proliferation, invasion, and migration of PANC-1 and PATU8988 cells, and induced their apoptosis Conclusions: Bergamottin effectively suppresses PC cell proliferation, invasion, and migration, and promotes apoptosis by regulating PPAR-γ. These findings suggest that bergamottin exhibits promising preclinical anti-tumor activity against PC.
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