ArticleFrontiers in rehabilitation sciences2026
Protective effects of early low-intensity exercise on the antigravity soleus muscle following focal cerebral infarction in rats.
Article in Frontiers in rehabilitation sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Skeletal muscle changes following stroke are a major factor influencing subsequent motor recovery. Objective: To examine the effects of early low-intensity exercise on motor function, neurological deficits, soleus muscle mass, fiber-type composition, and muscle fiber cross-sectional area following experimental stroke. Methods: Adult male Wistar rats were randomly assigned to ischemia-control (IC; Results: Compared to that in the IC group, the motor recovery and neurological function on day 28 were significantly greater in the IE group. The infarct volumes were initially comparable; however, the IE group exhibited a significant reduction beginning on day 5, and two-way ANOVA confirmed smaller infarct volumes in the IE group overall. The soleus muscle weight, fiber-type distribution, and cross-sectional area showed no significant temporal or between-group differences. Conclusions: Early exercise intervention promotes functional recovery and may attenuate lesion progression as assessed by TTC staining without detectable deterioration of soleus muscle morphology, highlighting the potential value of safe early mobilization after stroke.
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