ArticleFrontiers in cell and developmental biology2026
Dynamic regulation of hypothalamic NPY2R-positive primary cilia by nutritional states.
Article in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Primary cilia are specialized signaling organelles that concentrate selected G protein-coupled receptors and are important in neuronal and metabolic regulation. Neuropeptide Y receptor 2 (NPY2R), a receptor implicated in feeding and energy homeostasis, localizes to neuronal primary cilia in the hypothalamus. Although fasting-associated shortening of NPY2R-positive cilia in the arcuate nucleus (ARC) has recently been reported, it remains unclear whether this response reflects direct, ligand-driven structural remodeling of NPY2R-positive cilia, whether distinct nutritional states differentially regulate this receptor-defined ciliary compartment across feeding-related brain regions, and which intracellular mechanisms mediate these changes. Here, we show that neuropeptide Y (NPY) directly induces structural retraction of NPY2R-positive primary cilia, that nutritional states differentially remodel this receptor-defined ciliary compartment in a region-specific manner, and that NPY-driven ciliary retraction is mediated by Gi/o-dependent Akt/JNK signaling.
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