ArticleFrontiers in immunology2026
Detection of miRNA in chronic spontaneous urticaria patients - pilot study.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Chronic spontaneous urticaria (CSU) is a heterogeneous immune-mediated disorder characterized by recurrent wheals and/or angioedema. Despite advances in understanding its pathogenesis, robust biomarkers for disease stratification remain lacking. MicroRNAs (miRNAs) are key post-transcriptional regulators implicated in immune-mediated diseases and may provide novel insights into CSU. Objective: To characterize circulating miRNA expression profiles in CSU and explore their association with clinical phenotypes. Methods: Patients were stratified into three groups: urticaria only (n=10), urticaria with angioedema (n=10), and angioedema only (n=10), alongside healthy controls (n=10). Plasma miRNAs were sequenced using the NovaSeq 6000 platform. Data were processed with the nf-core smrnaseq pipeline, followed by multivariate and differential expression analyses in R. Functional enrichment and target prediction analyses were performed using KEGG, Reactome, and WikiPathways. Results: Thirty patients (mean age 45.3 years; 76.7% female) were included. Overall, 61 miRNAs were differentially expressed (p < 0.05) across groups, including controls. No miRNAs remained significant after multiple testing correction in pairwise comparisons between clinical subgroups. However, several miRNAs (miR-204-5p, miR-3158-3p, miR-4732-3p, miR-576-5p, and miR-877-5p) showed nominal associations with disease phenotypes. miR-204-5p demonstrated a trend toward reduced expression in patients with urticaria and angioedema (adjusted p = 0.05). Conclusion: Circulating miRNA profiles may reflect biological heterogeneity in CSU. Although no subgroup-specific signatures were confirmed after correction for multiple testing, several candidate miRNAs were identified, supporting further investigation of miRNA-based biomarkers in CSU.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.