ArticleFrontiers in pediatrics2026
Stability and compatibility of phentolamine mesylate combined with furosemide in common infusion solutions for pediatric critical care.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Intravenous phentolamine mesylate and furosemide are widely administered via infusion pumps to treat severe pediatric critical illnesses. Their off-label concurrent use lacks reliable physicochemical compatibility and stability data, bringing potential medication safety risks. This study aimed to evaluate the 8-hour compatibility and stability of the two drugs mixed in syringes under simulated clinical Methods: Two clinically relevant concentration gradients were set for testing: phentolamine mesylate at 0.1 and 0.5 mg·mL⁻ Results: Throughout the 8-hour observation period, all mixed solutions remained clear and colorless without precipitation, turbidity, or discoloration. The pH values remained stable with a fluctuation range within ±0.4 units. The number of insoluble particles complied with the standards specified in the 2020 edition of the Chinese Pharmacopoeia. Moreover, the relative percentage content of both phentolamine mesylate and furosemide remained above 95% at all time points. Conclusion: Under
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.