ArticleDiscover public health2026
Exploring the link between IgE-mediated inflammation and cardiorenal function in adults living with and without HIV.
Article in Discover public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Background: Immunoglobulin E (IgE) is traditionally recognized for its role in allergic response. However, emerging evidence suggests it may also influence cardiovascular, renal, and immune function. Understanding how IgE relates to endothelial function, electrolytes, renal markers, inflammatory mediators, and sociodemographic factors could provide insight into integrated cardiorenal-immune pathways and inform risk stratification people living with or without HIV. Methods: This cross-sectional study included 221 adults (median age 49 years, 68.3% female, 64.7% HIV-positive) at the medical clinic of Livingstone University Teaching Hospital. We collected data on sociodemographic characteristics, and performed diagnostic assessments for cardiometabolic health and inflammatory markers, including total IgE. To identify factors independently associated with IgE levels, we employed multiple linear regression models. Given the potential for HIV to modulate immune responses, all analyses were adjusted for relevant confounders, with statistical significance set at Results: In multivariable analysis of the overall cohort, log-transformed IgE levels were independently associated with serum creatinine (β = 2.26, 95% CI: 0.80-3.73, Conclusion: IgE levels in this HIV-endemic cohort were most consistently associated with renal function, with serum creatinine emerging as the only robust correlate after multiple testing correction. Additional associations with endothelial function, electrolytes, and behavioral factors were observed, particularly among people living with HIV, but remained exploratory. These findings suggest that IgE reflects a broader state of systemic immune activation rather than a specific driver of cardiorenal dysfunction. Longitudinal and mechanistic studies are needed to clarify causality and determine any prognostic relevance.
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