ArticleFrontiers in microbiology2026
Lactic acid bacteria-derived extracellular vesicles as postbiotic modulators of epithelial adhesion and barrier homeostasis: emerging perspectives.
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Microbiota-targeted strategies are increasingly moving beyond the administration of live microorganisms toward cell-free microbial components with postbiotic potential. Among these, extracellular vesicles released by lactic acid bacteria (LAB-derived EVs) are emerging as biologically active particles capable of transferring bacterial signals to host epithelial and immune cells. However, their effects should not be interpreted as uniform or intrinsically beneficial, because vesicle composition and activity are strongly influenced by bacterial strain, culture conditions, growth phase, isolation procedures and target cell context. In this Perspective, we discuss LAB-derived EVs as candidate postbiotic modulators of epithelial adhesion and barrier homeostasis. We focus on the epithelial interface as an integrated functional unit in which tight junctions, adherens junctions, junctional adhesion molecules, integrin-related cell-matrix adhesion, extracellular matrix remodeling and epithelial-immune communication converge. Evidence, largely derived from
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