Evidence map›Paper›PMID 42591263›Full record

ArticleFrontiers in cellular neuroscience2026

LRRK2 G2019S reprograms innate and adaptive immunity to drive context-dependent host defense outcomes.

Andrea R Merchak, Mary K Herrick, Madelyn C Houser, Dina A Moustafa, Joanna B Goldberg, Jeremy M Boss, Jacob Kohlmeier, Darcie M Cook, Cody E Keating, Jianjun Chang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Andrea R Merchak *Department of Neuroscience, University of Florida College of Medicine, Gainesville, FL, United States.
Mary K Herrick *Department of Physiology, School of Medicine, Emory University, Atlanta, GA, United States.
Madelyn C HouserDepartment of Physiology, School of Medicine, Emory University, Atlanta, GA, United States.
Dina A MoustafaDivision of Pulmonary, Asthma, Cystic Fibrosis, and Sleep, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, United States.
Joanna B GoldbergDivision of Pulmonary, Asthma, Cystic Fibrosis, and Sleep, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, United States.
Jeremy M BossDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, United States.
Jacob KohlmeierDepartment of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, United States.
Darcie M CookDepartment of Physiology, School of Medicine, Emory University, Atlanta, GA, United States.
Cody E KeatingDepartment of Physiology, School of Medicine, Emory University, Atlanta, GA, United States.
Jianjun ChangDepartment of Physiology, School of Medicine, Emory University, Atlanta, GA, United States.
Andrew B WestDuke Center for Neurodegeneration and Neurotherapeutic Research, Department of Pharmacology and Cancer Biology, Durham, NC, United States.
Malú Gámez TanseyDepartment of Neuroscience, University of Florida College of Medicine, Gainesville, FL, United States.

Funding

Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1M
Role of Gut Inflammation and Immunity on Proteostasis, Noradrenergic Degeneration and AD riskRF1AG057247 · NIA · UNIVERSITY OF FLORIDA · PI NEISH, ANDREW S, TANSEY, MARIA DE LOURDES GAMEZ · 2017 to 2017
$1.6M
NCATS NIH HHS UL1 TR002378NIA NIH HHS RF1 AG057247
6 · The paper itself

Abstract

Introduction: Parkinson's disease (PD) is increasingly recognized as a neurological disorder characterized not only by neurodegeneration but also by chronic immune dysregulation across the lifespan. Although the initiating events underlying PD remain unclear, accumulating evidence suggests that inflammatory processes may contribute to disease susceptibility and progression. Mutations in leucine-rich repeat kinase 2 ( Methods: Here, we used murine overexpression models of wildtype and G2019S variant of mouse Results: We found that Discussion: Together, these data show that

Indexed as

infectioninflammationLRRK2 G2019Smonocytesmyeloid cellsT cells

Identifiers

PMID42591263
PMCPMC13461538

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.