ArticleAdvances in drug and alcohol research2026
Distinct contributions of mu opioid and CB2 cannabinoid receptors to neuroimmune and behavioral responses.
Article in Advances in drug and alcohol research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Marijuana (cannabis) and cannabinoids are getting global medical and recreational approvals in this era of the opioid epidemic. Both opiates and cannabis are often co-abused, and their use increases the risk of opioid and cannabis use disorders (OUDs and CUDs), and dependency. Opioid and cannabinoid systems share many neuromodulating and pharmacological effects by activating opioid and cannabinoid receptors, respectively. Inflammation is increasingly implicated in many diseases, and mu-opioid receptor (MOR) and CB2 cannabinoid receptor (CB2R) have been linked to neuroinflammation. The hypothesis that changes in MOR and CB2R mediated behavioral and cytokine alterations are associated with their roles in inflammation was tested here. Naïve male C57Bl/6J as wild type, MOR KO mice with deletion of MOR, DAT-
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