ArticleFrontiers in nuclear medicine2026
MRI-derived T stage predicts nodal positivity on PSMA PET/CT in high-risk primary prostate cancer.
Article in Frontiers in nuclear medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Aim: We evaluated whether Magnetic Resonance Imaging (MRI)-Derived T Stage independently predicts nodal disease on Prostate-Specific Membrane Antigen (PSMA) PET/CT in patients with high-risk primary prostate cancer, and developed a predictive model for clinical decision support. Materials and methods: MRI-derived T Stage, Prostate-Specific Antigen (PSA), Gleason score, age and PSMA node status were analysed using univariable and multivariable logistic regression in 152 men with high-risk primary prostate cancer who underwent pre-treatment multiparametric MRI and PSMA PET/CT. Model performance was assessed with area under the receiver operating characteristic (ROC) curve (AUC), calibration plots, and decision curve analysis. Subgroup analyses evaluated Gleason 3 + 4 and 4 + 3 disease separately. Results: MRI T3b and T4 stages were independently and significantly associated with increased risk of PSMA-positive nodal disease ( Conclusion: MRI-derived T stage T3b disease is a strong independent predictor of PSMA-positive nodal disease. These findings support guideline-based staging criteria and support the integration of MRI-derived T Stage into PSMA PET/CT triage workflows.
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