Evidence map›Paper›PMID 42591213›Full record

ArticleFrontiers in oncology2026

MiRNA-140-3p affects the proliferation and metastasis of osteosarcoma via the UBE2C/PI3K-Akt axis.

Xu Yang, Yubo Xiang, Haoran Liu, Zhengchen Li, Zheng Luo, Jia Liu, Yongxin Bao, Yingxin Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xu Yang *Department of Rehabilitation Medicine, General Hospital of Northern Theater Command, Shenyang, China.
Yubo Xiang *Spinal Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, China.
Haoran Liu *Department of Orthopedic Surgery, The Forth Affiliated Hospital of China Medical University, Shenyang, China.
Zhengchen LiDepartment of Orthopedic Surgery, The Forth Affiliated Hospital of China Medical University, Shenyang, China.
Zheng LuoSpinal Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, China.
Jia LiuDepartment of Rehabilitation Medicine, General Hospital of Northern Theater Command, Shenyang, China.
Yongxin BaoDepartment of Rehabilitation Medicine, General Hospital of Northern Theater Command, Shenyang, China.
Yingxin YangDepartment of Rehabilitation Medicine, General Hospital of Northern Theater Command, Shenyang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The data of scRNA-seq in specific databases were analyzed by bioinformatics. The expression level of miR-140-3p in osteosarcoma cells was detected using qRT-PCR, and the correlation between the expression level of miR-140-3p and the survival of tumor patients was analyzed using a database. A series of experiments were conducted to explore the role of miR-140-3p in osteosarcoma cells. Database prediction of target genes, dual luciferase reporter gene experiments, and a series of

Indexed as

metastasismiR-140-3posteosarcomaPI3K/Akt pathwayUBE2C

Identifiers

PMID42591213
PMCPMC13461478

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.