SynthesisFrontiers in medicine2026
Global clinical landscape and multidisciplinary translational frontiers of FLASH radiotherapy: a systematic review and visualized bibliometric mapping based on WoSCC and PubMed (2014-2025).
Synthesis in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Ultra-high dose rate FLASH radiotherapy (FLASH-RT) holds the potential to revolutionize oncology by dramatically sparing normal tissue while maintaining tumor control. To capture both physical breakthroughs and biomedical translation, this study provides a comprehensive bibliometric mapping to evaluate the global research landscape and translational frontiers of FLASH-RT. Methods: To ensure maximum comprehensiveness, a systematic dual-database retrieval was conducted using the Web of Science Core Collection (WoSCC) and PubMed for articles published between January 1, 2014, and December 31, 2025. Following software-assisted deduplication using bibliometrix and independent, researcher-guided manual screening to exclude non-relevant document types, analytical protocols utilizing the R package bibliometrix, VOSviewer, and CiteSpace were applied to visualize publication trends, co-authorship networks, and keyword bursts. Results: A final analytical cohort of 807 high-quality articles was identified, revealing a rapidly accelerating, non-linear growth pattern relative to the 2014 baseline, with a marked surge after 2021, corresponding to the onset of prospective human FLASH-RT trials. The fitted annual-output trend followed a quadratic polynomial model with R Conclusion: By integrating extensive data from both WoSCC and PubMed, this study documents the safety-led maturation of FLASH-RT from an experimental physics curiosity to a viable clinical precision tool. The evolving synergy between dose-rate optimization and clinical oncology emphasizes that solving real-time dosimetric challenges remains the essential frontier for achieving widespread clinical adoption and widening the therapeutic window.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.