Evidence map›Paper›PMID 42591098›Full record

ArticleFrontiers in medicine2026

Genetics and epigenetics in tumor necrosis factor-alpha (

Bhagyalakshmi Shankarappa, Jayant Mahadevan, Pratima Murthy, Biju Viswanath, Harshad Devarbhavi, Sanjeev Jain, Meera Purushottam

Abstract read
In one paragraph

Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bhagyalakshmi ShankarappaMolecular Genetics Lab, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India.
Jayant MahadevanMolecular Genetics Lab, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India.
Pratima MurthyDepartment of Psychiatry, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India.
Biju ViswanathMolecular Genetics Lab, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India.
Harshad DevarbhaviDepartment of Gastroenterology, St. John's Medical College Hospital, Bangalore, India.
Sanjeev JainMolecular Genetics Lab, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India.
Meera PurushottamMolecular Genetics Lab, National Institute of Mental Health and Neurosciences (NIMHANS), Bangalore, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Alcohol dependence and cirrhosis are key outcomes of increased alcohol use, with genetic factors increasingly implicated. A functional promoter variant (rs361525) in the Methods: The study included men ( Results: Genotype and allele frequencies at both loci were comparable between AUD-C+ve and AUD-C-ve groups. Conclusion:

Indexed as

alcohol dependencealcohol liver cirrhosisDNA methylationTM6SF2TNF-alpha

Identifiers

PMID42591098
PMCPMC13461408

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.