ArticleCNS neuroscience & therapeutics2026
Predictors and a Nomogram for Parenchymal Hematoma After Endovascular Thrombectomy in Large Core Ischemic Stroke.
Article in CNS neuroscience & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveWe sought to establish a nomogram with internal validation to predict parenchymal hematoma (PH) following endovascular thrombectomy (EVT) in patients with large core infarcts.
methodsWe retrospectively enrolled 133 consecutive patients with large core anterior circulation infarctions receiving EVT from March 2018 to December 2024. Following univariable analysis (p < 0.1), LASSO and multivariable logistic regression were utilized to investigate predictive factors and establish a PH prediction nomogram. Model performance was assessed via ROC, calibration, decision, and clinical impact curves, with 1000-bootstrap internal validation. Subgroup analyses were stratified by age, baseline ASPECTS, and prior intravenous thrombolysis (IVT).
resultsPH occurred in 26 patients (19.5%). Baseline NIHSS score (OR 1.109, 95% CI 1.017-1.221; p = 0.023), monocytes (OR 0.002, 95% CI 9.74 × 10
conclusionsThis nomogram provides a robust tool for predicting post-thrombectomy PH in large core infarctions. The interaction between IVT and the number of passes potentially indicates minimizing unnecessary passes in direct thrombectomy. Multicenter prospective validation is warranted.
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