Metabolite-Driven Biological Activity of Mandragora autumnalis and Spartium junceum: A Comparative LC-MS/MS Study on Antioxidant, Cholinesterase, and Carbonic Anhydrase Inhibition.

Kubra Aslan, Esra Elbir, Yusuf Bicakci, Silanur Ozdogan, Mustafa Abdullah Yilmaz, Ilhami Gulcin

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Article in ChemistryOpen, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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Authors and funding

6 authors.

Kubra AslanDepartment of Chemistry, Faculty of Science, Ataturk University, Erzurum, Türkiye.ORCID 0000-0001-8388-5470

Esra ElbirDepartment of Molecular Biology and Genetics, Faculty of Science, Ataturk University, Erzurum, Türkiye.

Yusuf BicakciDepartment of Chemistry, Faculty of Science, Ataturk University, Erzurum, Türkiye.

Silanur OzdoganDepartment of Molecular Biology and Genetics, Faculty of Science, Ataturk University, Erzurum, Türkiye.

Mustafa Abdullah YilmazDepartment of Analytical Chemistry, Faculty of Pharmacy, Dicle University, Diyarbakir, Türkiye.ORCID 0000-0002-4090-7227

Ilhami GulcinDepartment of Chemistry, Faculty of Science, Ataturk University, Erzurum, Türkiye.ORCID 0000-0001-5993-1668

Funding

Türkiye Bilimsel ve Teknolojik Araştırma Kurumu

6 · The paper itself

Abstract

In this study, the targeted phytochemical profiles and multi-target biological activities of Mandragora autumnalis L. and Spartium junceum L. were evaluated using liquid chromatography-tandem mass spectrometry (LC-MS/MS), antioxidant, enzyme inhibition, and antimicrobial assays. LC-MS/MS analysis showed that M. autumnalis predominantly contained low-molecular-weight phenolic acids, particularly protocatechuic acid (0.6850 µg/mg), whereas S. junceum was richer in flavonoids and isoflavonoids, especially genistein (1.8280 µg/mg) and cynaroside (1.5240 µg/mg). M. autumnalis showed stronger antioxidant activity, with a DPPH IC

Indexed as

AntioxidantsCarbonic Anhydrase InhibitorsCholinesterase InhibitorsPlant ExtractsAnti-Bacterial AgentsCarbonic AnhydrasesChromatography, LiquidFlavonoidsLiquid Chromatography-Mass SpectrometryTandem Mass SpectrometryAnti-Bacterial AgentsAntioxidantsCarbonic Anhydrase InhibitorsCarbonic AnhydrasesCholinesterase InhibitorsFlavonoidsPlant Extractsantioxidantenzyme inhibitionMandragora autumnalisneurodegenerative disordersSpartium junceum

Identifiers

PMID42590968

DOI10.1002/open.70269

PMCPMC13470032

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.