Evidence map›Paper›PMID 42590909›Full record

ArticleJournal of immunology research2026

Cyclodextrin Inhibits Caveolin-1 to Regulate CD4

Yajie Gao, Peiyao Zhang, Yinping Huo, Yongfu Wang, Lingyan Zhu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Cyclodextrin Inhibits Caveolin-1 to Regulate CD4Journal of immunology research · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yajie GaoThe Central Lab, The First Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia, China, btmc.cn.ORCID https://orcid.org/0000-0002-9883-266X
Peiyao ZhangDepartment of Infectious Diseases, Inner Mongolia People's Hospital, Hohhot, Inner Mongolia, China, nmgyy.cn.ORCID https://orcid.org/0009-0002-1880-3875
Yinping HuoThe Central Lab, The First Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia, China, btmc.cn.ORCID https://orcid.org/0009-0008-6657-2155
Yongfu WangDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia, China, btmc.cn.ORCID https://orcid.org/0000-0002-8698-8915
Lingyan ZhuDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia, China, btmc.cn.ORCID https://orcid.org/0009-0008-3933-0345

Funding

National Natural Science Foundation of China 82160309Natural Science Foundation of Inner Mongolia 2025LHMS08006Natural Science Foundation of Inner Mongolia 2025QN08069Science and Technology Program of the Joint Fund of Scientific Research for the Public Hospitals of Inner Mongolia Academy of Medical Sciences 2024GLLH0527Young and Middle-aged Scientific and Technological Backbone Support Program of Baotou Medical College BYJJ-QNGG202401
6 · The paper itself

Abstract

objectiveRheumatoid arthritis (RA) is a systemic autoimmune disease characterized by dynamically recurring inflammatory episodes, and targeting T cells has been shown to effectively alleviate RA. Caveolin-1 (CAV-1) is widely distributed in the membrane structures of immune cells and participates in the differentiation and homeostasis of CD4

methodsThis retrospective clinical study was conducted to detect serum CAV-1 levels in RA and healthy controls (HCs), characterize its expression in peripheral blood CD4

resultsCAV-1 expression in serum, CD4

conclusionCAV-1 is aberrantly upregulated in RA and contributes to disease pathogenesis by regulating CD4

Indexed as

Arthritis, ExperimentalArthritis, RheumatoidCaveolin 1CD4-Positive T-LymphocytesT-Lymphocyte SubsetsAdultAnimalsCell DifferentiationCytokinesDisease Models, AnimalDisease ProgressionFemaleHumansMaleMiceMiddle AgedCaveolin 1Cytokinescaveolin-1cyclodextrinrheumatoid arthritisT cellT cell differentiation

Identifiers

PMID42590909
PMCPMC13469748

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.