SynthesisInternational journal of rheumatic diseases2026
Effectiveness of Platelet-Rich Plasma in Knee Osteoarthritis: A Systematic Review and Meta-Analysis.
Synthesis in International journal of rheumatic diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
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Abstract
introductionKnee osteoarthritis (OA) causes chronic pain and disability, with limited benefit from conventional treatments. Platelet-rich plasma (PRP) has been proposed as a biologic therapy with potential tissue-repair properties; however, its clinical efficacy remains uncertain.
objectiveTo assess the effectiveness of intra-articular PRP injections in reducing pain and improving function in patients with knee OA. METHODOLOGY: This systematic review and meta-analysis included randomized controlled trials comparing intra-articular PRP with placebo or no treatment. Pain outcomes were measured using the Visual Analog Scale (VAS), while functional outcomes were assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) or Knee injury and Osteoarthritis Outcome Score (KOOS).
resultsPRP significantly reduced pain and improved function compared with placebo across short-, mid-, and long-term follow-up. The magnitude of benefit varied but remained clinically relevant.
conclusionPRP provides significant improvements in pain relief and functional outcomes compared with placebo or no treatment in patients with knee OA, supporting its potential as a therapeutic option. Standardized protocols and larger RCTs are warranted to further confirm its clinical effectiveness.
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