Bacterial Outer Membrane Vesicle-Based Versatile In Situ Nanovaccine Enhancer Synergized With Radiofrequency Ablation Against Hepatocellular Carcinoma.

Yongchao Li, Kecheng Liu, Jingpei Guo, Shengyu Wang, Yang Sun, Junfeng Liu, Menghui Liu, Jingqin Cao

Abstract read

In one paragraph

Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yongchao LiDepartment of Interventional Radiology, Jining Key Laboratory of Stroke and Neural Repair, Jining Academy of Medical Sciences, Jining NO.1 People's Hospital, Jining, China.

Kecheng LiuMedical Research Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.

Jingpei GuoDepartment of Interventional Medicine, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, China.

Shengyu WangDepartment of Gastrointestinal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Yang SunDepartment of Interventional Medicine, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, China.

Junfeng LiuDepartment of Interventional Therapy, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Center, Sichuan Cancer Hospital & Institute, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China.

Menghui LiuDepartment of Radiology, Xiangya Hospital, Central South University, Changsha, China.ORCID https://orcid.org/0009-0009-3945-7554

Jingqin CaoDepartment of Interventional Radiology, Jining Key Laboratory of Stroke and Neural Repair, Jining Academy of Medical Sciences, Jining NO.1 People's Hospital, Jining, China.ORCID https://orcid.org/0009-0001-9028-1277

Funding

China Postdoctoral Science Foundation 2025M772132Key R&D Program of Jining 2025YXNS123PhD Research Fund of Jining NO.1 People's Hospital 2025-BS-004

6 · The paper itself

Abstract

Radiofrequency ablation (RFA) is the primary curative therapy for early hepatocellular carcinoma (HCC). However, incomplete ablation inevitably occurs in clinical practice, leaving residual tumors that are highly immunosuppressive, refractory to immune checkpoint inhibitors, and prone to recurrence and metastasis. To address this, we developed a novel nanoformulation, OMV

Indexed as

Bacterial Outer MembraneCancer VaccinesCarcinoma, HepatocellularLiver NeoplasmsNanovaccinesRadiofrequency AblationAnimalsCell Line, TumorHumansMiceCancer VaccinesNanovaccinesengineered bacterial outer membrane vesiclehepatocellular carcinomaradiofrequency ablationtumor vaccine

Identifiers

PMID42590861

DOI10.1002/adhm.71589

PMCPMC13568969

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.