Evidence map›Paper›PMID 42589841›Full record

ArticlePolymers2026

Fabrication, Simulation, and Mechanical Characterization of Curcumin-Loaded PVA/PVP Microneedle Arrays Using Custom 3D-Printed Molds.

Bryan Angelo S J Basa, Charlize Dawn Z Batin, Izabelle Nisha Maxine D Chan, Adrian Ray B Gabay, John Ray C Estrellado, Ron Gilbert R Rallos, Mary Stephanie S Carranza, Mark Jefferson U Lim, Jubert C Marquez, Joseph Rey H Sta Agueda

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Polymers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bryan Angelo S J BasaDepartment of Manufacturing Engineering and Management, De La Salle University, Manila 1004, Philippines.ORCID 0009-0009-6319-0044
Charlize Dawn Z BatinDepartment of Manufacturing Engineering and Management, De La Salle University, Manila 1004, Philippines.ORCID 0009-0004-5090-3811
Izabelle Nisha Maxine D ChanDepartment of Manufacturing Engineering and Management, De La Salle University, Manila 1004, Philippines.ORCID 0009-0009-1942-8801
Adrian Ray B GabayDepartment of Manufacturing Engineering and Management, De La Salle University, Manila 1004, Philippines.ORCID 0009-0006-9221-5704
John Ray C EstrelladoDepartment of Manufacturing Engineering and Management, De La Salle University, Manila 1004, Philippines.ORCID 0000-0002-5789-1380
Ron Gilbert R RallosCenter of Engineering and Sustainable Development Research, De La Salle University, Manila 1004, Philippines.ORCID 0009-0002-8132-6709
Mary Stephanie S CarranzaCenter of Engineering and Sustainable Development Research, De La Salle University, Manila 1004, Philippines.ORCID 0000-0001-9717-0062
Mark Jefferson U LimCenter of Engineering and Sustainable Development Research, De La Salle University, Manila 1004, Philippines.ORCID 0009-0005-0683-8503
Jubert C MarquezCardiovascular and Metabolic Disease Center, Paik Hospital, Inje University, Busan 47392, Republic of Korea.ORCID 0000-0002-8541-4362
Joseph Rey H Sta AguedaDepartment of Manufacturing Engineering and Management, De La Salle University, Manila 1004, Philippines.ORCID 0000-0002-6671-4079

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microneedle (MN) arrays offer a novel and minimally invasive platform for transdermal drug delivery. This study presents an approach for the design and fabrication of MN array models for biomedical applications using custom 3D-printed micro-molds. Material analysis of the polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP) matrix in a 3:1 weight ratio was conducted under varying geometric configurations, curcumin (CUR) dosages, and target penetration depths of 300 to 500 μm. Computational simulation using computer-aided design (CAD) and finite element analysis (FEA) on ANSYS (Canonsburg, PN, USA) measured for total deformation, stress distribution, insertion pressure, and factor of safety. Elimination criteria were applied, narrowing down to specific models that were experimentally validated through material formulation, micro-molding, and material characterization. The selected MN models were analyzed by insertion and penetration efficiency testing on porcine skin. The results showed that higher CUR concentrations reduced mechanical strength and Young's modulus, while mid-range dosages (2-6 mg) combined with optimized geometric spacing produced MNs with maintained structural integrity and effective performance. Conical microneedles demonstrated the most favorable balance of mechanical stability, controlled swelling behavior, and high insertion efficiency. The study recommends this approach as a feasible and reproducible method for localized wound-healing applications.

Indexed as

3D printingcurcuminfinite element analysisMicroneedle arrays

Identifiers

PMID42589841
PMCPMC13468145

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.