Evidence map›Paper›PMID 42589702›Full record

ReviewInternational journal of molecular sciences2026

Current Advances in the Physiological Roles and Disease-Associated Mechanisms of ADAMTS16.

Linxiu Wang, Jiazhen Zhang, Yuying Zhang

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Linxiu WangSchool of Biological Science and Technology, University of Jinan, Jinan 250022, China.
Jiazhen ZhangSchool of Biological Science and Technology, University of Jinan, Jinan 250022, China.
Yuying ZhangSchool of Biological Science and Technology, University of Jinan, Jinan 250022, China.ORCID 0009-0006-2520-5055

Funding

National Natural Science Foundation of China 32372994
6 · The paper itself

Abstract

As an important member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family, ADAMTS16 participates in various physiological and pathological processes through the regulation of extracellular matrix (ECM) components. This review systematically delineates the expression profiles of ADAMTS16 in different tissues and cell types, as well as its diverse roles in reproductive development, cardiovascular diseases, ocular diseases, skeletal disorders, malignancies, and other pathological conditions, revealing significant differences in its expression patterns and mechanisms of action across various tissues. Cumulatively, current evidence suggests that ADAMTS16 may engage in direct or indirect interactions with ECM constituents to regulate cell proliferation, differentiation, and migration, and may also influence a range of cellular activities via synergistic cooperation with other cytokines.

Indexed as

ADAMTS ProteinsAnimalsExtracellular MatrixHumansNeoplasmsSignal TransductionADAMTS16 protein, humanADAMTS ProteinsADAMTS16cancerextracellular matrixreproductive developmentTGF-β signaling

Identifiers

PMID42589702
PMCPMC13466815

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.