ArticleInternational journal of molecular sciences2026
RAN Translation-Coupled Decay of the
You Wu, Li Li, Jing Tian, Leilei Liu, Kunzhao Du, Zhicheng Shao, Tianlin Cheng, Xin Cao, Tao Wang
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
9 authors.
You WuInstitute of Clinical Sciences, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Li LiInstitute of Clinical Sciences, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Jing TianInstitute of Clinical Sciences, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Leilei LiuInstitute of Clinical Sciences, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Kunzhao DuInstitute of Clinical Sciences, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Zhicheng ShaoInstitute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200031, China.
Tianlin ChengInstitute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200031, China.
Xin CaoInstitute of Clinical Sciences, Zhongshan Hospital, Fudan University, Shanghai 200032, China.ORCID 0000-0003-1722-023X Tao WangInstitute of Clinical Sciences, Zhongshan Hospital, Fudan University, Shanghai 200032, China.ORCID 0000-0002-8177-0298 Funding
National Natural Science Foundation of China 32271000National Natural Science Foundation of China 32300796National Natural Science Foundation of China 32471008National Science and Technology Innovation 2030 Major Projects of China STI2030-Major Projects-2022ZD0212600Natural Science Foundation of Shanghai 23ZR1413800
6 · The paper itselfAbstract
The RNA exosome plays a critical role in surveilling nuclear mRNA biogenesis and regulating co-translational mRNA decay in the cytoplasm. Unlike canonical translation, repeat-associated non-AUG (RAN) translation of a GGGGCC hexanucleotide repeat expansion (HRE) within an intron of the
Indexed as
C9orf72 ProteinDipeptidesDNA Repeat ExpansionExosome Multienzyme Ribonuclease ComplexProtein BiosynthesisRNA StabilityAmyotrophic Lateral SclerosisFrontotemporal DementiaHumansInduced Pluripotent Stem CellsNeuronsRNA, MessengerC9orf72 ProteinC9orf72 protein, humanDipeptidesExosome Multienzyme Ribonuclease ComplexRNA, MessengerC9orf72-ALSco-translational regulationmRNA stabilityRAN translationRNA exosome
Identifiers
PMID42589639
PMCPMC13466912
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