Evidence map›Paper›PMID 42589596›Full record

ArticleInternational journal of molecular sciences2026

Distinct Modulation of High- and Low-Frequency Activity by Midazolam and Neurosteroids in Neocortical Slices.

Stefan Bieletzki, Clara Gotthard, Xènia Puig-Bosch, Hanns Ulrich Zeilhofer, Uwe Rudolph, Gerhard Rammes, Bernd Antkowiak, Berthold Drexler

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Stefan BieletzkiDepartment of Anesthesiology and Intensive Care Medicine, Experimental Anesthesiology Section, Eberhard Karls University, 72076 Tübingen, Germany.
Clara GotthardDepartment of Anesthesiology and Intensive Care Medicine, Experimental Anesthesiology Section, Eberhard Karls University, 72076 Tübingen, Germany.
Xènia Puig-BoschDepartment of Anesthesiology and Intensive Care Medicine, Medical School, Klinikum rechts der Isar, Technical University Munich, 81675 Munich, Germany.
Hanns Ulrich ZeilhoferInstitute of Pharmacology and Toxicology, University of Zurich, 8057 Zurich, Switzerland.ORCID 0000-0001-6954-4629
Uwe RudolphDepartment of Comparative Biosciences, College of Veterinary Medicine, and Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.ORCID 0000-0001-9396-4746
Gerhard RammesDepartment of Anesthesiology and Intensive Care Medicine, Medical School, Klinikum rechts der Isar, Technical University Munich, 81675 Munich, Germany.ORCID 0000-0002-1698-4257
Bernd AntkowiakDepartment of Anesthesiology and Intensive Care Medicine, Experimental Anesthesiology Section, Eberhard Karls University, 72076 Tübingen, Germany.
Berthold DrexlerDepartment of Anesthesiology and Intensive Care Medicine, Experimental Anesthesiology Section, Eberhard Karls University, 72076 Tübingen, Germany.ORCID 0000-0001-7202-1511

Funding

Deutsche Forschungsgemeinschaft AN321/5-1Deutsche Forschungsgemeinschaft RA689/14-1
6 · The paper itself

Abstract

Adverse effects of benzodiazepines are largely mediated by GABA

Indexed as

Action PotentialsMidazolamNeocortexNeurosteroidsAnimalsMicePregnanoloneReceptors, GABA-AMidazolamNeurosteroidsPregnanoloneReceptors, GABA-Aelectroencephalographic activityGABAA-subtypesneocortexorganotypic culturessedationtranslocator protein (18 kD)up-states

Identifiers

PMID42589596
PMCPMC13466293

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.