Evidence map›Paper›PMID 42589556›Full record

ArticleInternational journal of molecular sciences2026

WSB1-Mediated PSMA Ubiquitination Promotes Enzalutamide-Induced Neuroendocrine-like Transition in Patient-Derived Prostate Cancer Spheroids.

Dawa Jung, Ayse Tuba Kendi, David A Woodrum, Daniel A Adamo, Scott M Thompson, Myung-Ho In, Gokce Belge Bilgin, Derek R Johnson, Ian M Horn, Eun-Joo Kim and 5 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Dawa JungDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Ayse Tuba KendiDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0003-3892-4754
David A WoodrumDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Daniel A AdamoDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Scott M ThompsonDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Myung-Ho InDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0001-8001-6237
Gokce Belge BilginDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Derek R JohnsonDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-4217-5517
Ian M HornDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Eun-Joo KimDepartment of Molecular Biology, Dankook University, Cheonan 31116, Republic of Korea.
Jin Ook ChungDepartment of Internal Medicine, Chonnam National University Medical School, Gwangju 501757, Republic of Korea.
Seon-Young ParkDepartment of Internal Medicine, Chonnam National University Medical School, Gwangju 501757, Republic of Korea.
Geoffry L CurranDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Val J LoweDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-5612-1667
SeungBaek LeeDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-4754-4481

Funding

Mayo Clinic Center for Clinical and Translational Science (CCaTS)-Vranos Family Foundation: FD135390
6 · The paper itself

Abstract

Long-established prostate cancer cell lines provide limited insight into how contemporary early prostate cancer evolves into drug-resistant and neuroendocrine-like refractory disease. Patient-derived three-dimensional (3D)

Indexed as

Antigens, SurfaceGlutamate Carboxypeptidase IIPhenylthiohydantoinProstatic NeoplasmsSpheroids, CellularAurora Kinase ABenzamidesCell Line, TumorDrug Resistance, NeoplasmHumansMaleNeuroendocrine TumorsNitrilesProstate-Specific AntigenUbiquitinationAntigens, SurfaceAurora Kinase ABenzamidesenzalutamideFOLH1 protein, humanGlutamate Carboxypeptidase IINitrilesPhenylthiohydantoinProstate-Specific AntigenAurora kinase Aenzalutamide resistancepatient-derived spheroidsprostate cancerprostate-specific membrane antigentreatment-emergent neuroendocrine prostate cancerWSB1

Identifiers

PMID42589556
PMCPMC13466754

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.