ArticleInternational journal of molecular sciences2026
Virtual Screening, Synthesis and In Vitro Characterization of Histamine H
Olga Michalak, Marcin Cybulski, Piotr Krzeczyński, Oliwia Zegrocka-Stendel, Małgorzata Dutkiewicz, Dorota Dymkowska, Agnieszka Olejarz-Maciej, Tadeusz Karcz, Mariam Dubiel, Pakhuri Mehta and 8 more
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
18 authors.
Olga MichalakPharmacy, Cosmetic Chemistry and Biotechnology Research Group, Łukasiewicz Research Network-Industrial Chemistry Institute, 8 Rydygiera Str., 01-793 Warsaw, Poland.ORCID 0000-0002-1067-4223 Marcin CybulskiPharmacy, Cosmetic Chemistry and Biotechnology Research Group, Łukasiewicz Research Network-Industrial Chemistry Institute, 8 Rydygiera Str., 01-793 Warsaw, Poland.ORCID 0000-0002-4560-9317 Piotr KrzeczyńskiPharmacy, Cosmetic Chemistry and Biotechnology Research Group, Łukasiewicz Research Network-Industrial Chemistry Institute, 8 Rydygiera Str., 01-793 Warsaw, Poland.ORCID 0000-0002-4978-5887 Oliwia Zegrocka-StendelDepartment of Biochemistry and Nutrition, Centre for Preclinical Research and Technologies, Medical University of Warsaw, 1b Stefana Banacha Str., 02-097 Warsaw, Poland.
Małgorzata DutkiewiczDepartment of Biochemistry and Nutrition, Centre for Preclinical Research and Technologies, Medical University of Warsaw, 1b Stefana Banacha Str., 02-097 Warsaw, Poland.ORCID 0000-0002-5701-7490 Dorota DymkowskaLaboratory of Cellular Metabolism, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Ludwika Pasteura Str., 02-093 Warsaw, Poland.ORCID 0000-0003-4798-4062 Agnieszka Olejarz-MaciejDepartment of Chemical Technology and Biotechnology of Drugs, Jagiellonian University Medical College, 9 Medyczna Str., 30-688 Kraków, Poland.ORCID 0000-0002-1466-0742 Tadeusz KarczDepartment of Chemical Technology and Biotechnology of Drugs, Jagiellonian University Medical College, 9 Medyczna Str., 30-688 Kraków, Poland.ORCID 0000-0003-4035-659X Mariam DubielInstitute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitaetsstrasse 1, 40225 Duesseldorf, Germany.ORCID 0000-0003-2055-4935 Pakhuri MehtaFaculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, 1 Pasteura Str., 02-093 Warsaw, Poland.ORCID 0000-0003-2317-273X Marek KubiszewskiAnalytical Research Section, Pharmaceutical Analysis Laboratory, Łukasiewicz Research Network-Industrial Chemistry Institute, 8 Rydygiera Str., 01-793 Warsaw, Poland.
Marcin LorkowskiFaculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, 1 Pasteura Str., 02-093 Warsaw, Poland.
Jakub JakowieckiFaculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, 1 Pasteura Str., 02-093 Warsaw, Poland.ORCID 0000-0001-5882-1029 Paweł PasznikFaculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, 1 Pasteura Str., 02-093 Warsaw, Poland.
Przemysław MisztaFaculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, 1 Pasteura Str., 02-093 Warsaw, Poland.
Holger StarkInstitute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitaetsstrasse 1, 40225 Duesseldorf, Germany.ORCID 0000-0003-3336-1710 Katarzyna KoziakDepartment of Biochemistry and Nutrition, Centre for Preclinical Research and Technologies, Medical University of Warsaw, 1b Stefana Banacha Str., 02-097 Warsaw, Poland.ORCID 0000-0003-0612-7646 Sławomir FilipekFaculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw, 1 Pasteura Str., 02-093 Warsaw, Poland.ORCID 0000-0003-3147-3858 Funding
National Science Centre OPUS 2022/45/B/NZ7/04246
6 · The paper itselfAbstract
Histamine is a biologically active monoamine acting through four
Indexed as
Histamine AntagonistsPyrimidinesReceptors, Histamine H4Cyclic AMPHumansLigandsMolecular Docking SimulationProtein BindingStructure-Activity RelationshipCyclic AMPHistamine AntagonistsHRH4 protein, humanLigandspyrimidinePyrimidinesReceptors, Histamine H44-methylhistamineagonistantagonistcAMP accumulationcytosolic calcium influxH4Rhistaminehistamine H4 receptorradioligand bindingvirtual screeningβ-arrestin recruitment
Identifiers
PMID42589546
PMCPMC13466428
What OpenQuestion holds
Textmetadata
Read underepoch 390