Evidence map›Paper›PMID 42589531›Full record

ArticleInternational journal of molecular sciences2026

Prevalence of Mismatch Repair Deficiency and Its Association with Histopathological Parameters in Endometrial Cancer: A Prospective Cohort Study.

Emmanouela-Aliki Almperi, Chrysoula Margioula-Siarkou, Aristarchos Almperis, Tibor A Zwimpfer, Alexandros Daponte, Nikoletta Daponte, Thomas Vrekoussis, Theodora Papamitsou, Konstantinos Dinas, Stamatios Petousis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Emmanouela-Aliki AlmperiGynaecologic Oncology Unit, 2nd Department of Obstetrics and Gynaeocology, Aristotle University of Thessaloniki, 54622 Thessaloniki, Greece.ORCID 0000-0003-3502-0143
Chrysoula Margioula-SiarkouGynaecologic Oncology Unit, 2nd Department of Obstetrics and Gynaeocology, Aristotle University of Thessaloniki, 54622 Thessaloniki, Greece.
Aristarchos AlmperisGynaecologic Oncology Unit, 2nd Department of Obstetrics and Gynaeocology, Aristotle University of Thessaloniki, 54622 Thessaloniki, Greece.
Tibor A ZwimpferGynecological Cancer Centre, University Hospital Basel, University of Basel, 4031 Basel, Switzerland.
Alexandros DaponteDepartment of Obstetrics and Gynaecology, Medical School, University of Thessaly, 41500 Larissa, Greece.
Nikoletta DaponteDepartment of Obstetrics and Gynaecology, Medical School, University of Thessaly, 41500 Larissa, Greece.
Thomas VrekoussisLaboratory of Human Reproduction, Department of Obstetrics and Gynecology, Medical School, University of Crete, 70013 Heraklion, Greece.ORCID 0000-0002-6347-7223
Theodora PapamitsouLaboratory of Histology-Embryology, Department of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.ORCID 0000-0002-0709-5407
Konstantinos DinasGynaecologic Oncology Unit, 2nd Department of Obstetrics and Gynaeocology, Aristotle University of Thessaloniki, 54622 Thessaloniki, Greece.ORCID 0000-0001-7144-2840
Stamatios PetousisGynaecologic Oncology Unit, 2nd Department of Obstetrics and Gynaeocology, Aristotle University of Thessaloniki, 54622 Thessaloniki, Greece.ORCID 0000-0002-5564-0406

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mismatch repair deficiency (MMRd) is a critical biomarker in endometrial cancer (EC) for prognostication, Lynch syndrome screening, and immunotherapy eligibility. This study aimed to determine the prevalence of MMRd and its correlation with clinicopathological characteristics in EC. This prospective observational cohort included 93 patients with EC undergoing primary surgical treatment, managed as per the European Society of Gynaecological Oncology (ESGO) guidelines.

Indexed as

Brain NeoplasmsColorectal NeoplasmsDNA Mismatch RepairEndometrial NeoplasmsNeoplastic Syndromes, HereditaryAgedDNA-Binding ProteinsFemaleHumansMiddle AgedMismatch Repair Endonuclease PMS2MutL Protein Homolog 1PrevalenceProspective StudiesDNA-Binding ProteinsMismatch Repair Endonuclease PMS2MLH1 protein, humanMutL Protein Homolog 1endometrial cancerhistopathologyimmunohistochemistryLynch syndromemismatch repair deficiencymolecular classificationmyometrial invasion

Identifiers

PMID42589531
PMCPMC13466416

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.