Evidence map›Paper›PMID 42589516›Full record

ArticleInternational journal of molecular sciences2026

Dietary Acidifier Modulates the Gut Microbiota-Metabolic Axis to Improve Intestinal Health, Yolk Fatty Acid Profiles, and Egg Quality in Laying Hens.

Xiaotong Li, Qiaoqiao Han, Yaru Wang, Yue Wang, Zuowei Li, Sheng Wang, Wei Fu, Huiying Li, Haihua Zhang, Donghui Shi and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiaotong LiState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Qiaoqiao HanState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Yaru WangState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.ORCID 0009-0001-0904-6617
Yue WangState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Zuowei LiState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Sheng WangState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Wei FuState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Huiying LiState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.
Haihua ZhangHebei Key Laboratory of Specialty Animal Germplasm Resources Exploration and Innovation, College of Animal Science and Technology, Hebei Normal University of Science and Technology, Qinhuangdao 066004, China.
Donghui ShiCollege of Animal Science and Veterinary Medicine, Jinzhou Medical University, Jinzhou 121001, China.
Shimeng HuangState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China.

Funding

Agricultural Guiding (Key) Project of the Fujian Provincial Department of Science and Technology 2024N0014Chinese Universities Scientific Fund Chinese Universities Scientific FundFujian Provincial Modern Agricultural Industry Technology System - Poultry Industry Technology System Project 2025Modern Agricultural Industrial Technology System in Hebei Province HBCT2023210202National Natural Science Foundation of China 32472952Special Fund for the China Agricultural Research System CARS-40-K08
6 · The paper itself

Abstract

Acidifiers are functional feed additives that may improve egg quality by modulating intestinal microbiota and host metabolism. This study investigated the effects of dietary acidifier supplementation on laying performance, yolk fatty acid composition, eggshell ultrastructure, intestinal function, cecal microbiota, serum metabolome, and antioxidant status in laying hens. Sixty 52-week-old Jingfen No. 6 laying hens were randomly assigned to either a control group or an acidifier-supplemented group for 6 weeks. Acidifier supplementation increased laying rate and egg mass while reducing the feed-to-egg ratio. It also increased the concentrations of seven yolk fatty acids, including tetradecanoic acid, myristoleic acid, palmitic acid, palmitoleic acid, stearic acid, cis-vaccenic acid, and arachidic acid. In addition, acidifier supplementation resulted in a denser eggshell microstructure, improved cecal mucosal morphology, and enhanced the activities of lipase, chymotrypsin, amylase, and trypsin. Although cecal microbial alpha diversity remained unchanged, acidifier supplementation altered the overall microbial community structure and enriched several genera, including

Indexed as

ChickensEggsEgg YolkFatty AcidsGastrointestinal MicrobiomeIntestinesAnimal FeedAnimalsCecumDietDietary SupplementsEgg ShellFemaleMetabolomeFatty Acidsacidifieregg qualitygut microbiomelaying henslipid metabolismyolk fatty acid composition

Identifiers

PMID42589516
PMCPMC13467168

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.