Dexpanthenol Attenuates High-Fructose Corn Syrup-Induced Hepatic Injury in Young Adult Rats by Modulating Oxidative Stress, Apoptosis, and Inflammasome-Associated Pyroptotic Signaling.

Abdulkerim Elmas, Halil Asci, Muhammet Yusuf Tepebasi, Muhammed Burak Selver, Ilter Ilhan, Mustafa Akcam, Ozlem Ozmen

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Abdulkerim ElmasDivision of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Faculty of Medicine, Suleyman Demirel University, Isparta 32100, Türkiye.ORCID 0009-0002-3788-8325

Halil AsciDepartment of Pharmacology, Faculty of Medicine, Suleyman Demirel University, Isparta 32100, Türkiye.

Muhammet Yusuf TepebasiDepartment of Genetics, Faculty of Medicine, Suleyman Demirel University, Isparta 32100, Türkiye.ORCID 0000-0002-1087-4874

Muhammed Burak SelverDepartment of Pediatrics, Faculty of Medicine, Suleyman Demirel University, Isparta 32100, Türkiye.ORCID 0000-0001-8763-525X

Ilter IlhanDepartment of Medical Biochemistry, Faculty of Medicine, Suleyman Demirel University, Isparta 32100, Türkiye.ORCID 0000-0003-3739-9580

Mustafa AkcamDivision of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Faculty of Medicine, Suleyman Demirel University, Isparta 32100, Türkiye.

Ozlem OzmenDepartment of Pathology, Faculty of Veterinary Medicine, Burdur Mehmet Akif Ersoy University, Burdur 15030, Türkiye.ORCID 0000-0002-1835-1082

Funding

Süleyman Demirel University TSG-2025-9598

6 · The paper itself

Abstract

Excessive intake of high-fructose corn syrup (HFCS) contributes to pediatric metabolic dysfunction-associated steatotic liver disease, but the mechanisms linking fructose exposure to inflammatory cell death remain incompletely defined. This study investigated whether dexpanthenol (DEX) attenuates HFCS-induced liver injury by modulating oxidative stress, apoptosis, and nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome-associated pyroptotic signaling. Thirty-two young adult male Wistar rats were assigned to control, HFCS, HFCS+DEX, and DEX groups (

Indexed as

ApoptosisChemical and Drug Induced Liver InjuryHigh Fructose Corn SyrupInflammasomesOxidative StressAnimalsCaspase 1Caspase 3GasderminsInterleukin-1betaLiverMaleNLR Family, Pyrin Domain-Containing 3 ProteinPhosphate-Binding ProteinsRatsRats, WistarCaspase 1Caspase 3GasderminsGsdmd protein, ratHigh Fructose Corn SyrupInflammasomesInterleukin-1betaNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, ratPhosphate-Binding Proteinsgasdermin Dlipid peroxidationmetabolic dysfunction-associated steatotic liver diseaseNLRP3 inflammasomepyroptosisyoung adult rat model

Identifiers

PMID42589483

DOI10.3390/ijms27156828

PMCPMC13467043

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.