Evidence map›Paper›PMID 42589452›Full record

ArticleInternational journal of molecular sciences2026

Design, Synthesis, and Biological Evaluation of Trifluoromethylated 1,2,4-Triazin-6-ones with Selective Antimycotic Activity and Hormesis Effects.

Anna Kowalczyk, Aleksandra Trębska, Milena Sęczkowska, Katarzyna Gach-Janczak, Anita Ciesielska, Paweł Stączek, Marcin Jasiński

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anna KowalczykDepartment of Organic and Applied Chemistry, Faculty of Chemistry, University of Lodz, Tamka 12, 91-403 Łódź, Poland.ORCID 0000-0002-4775-2694
Aleksandra TrębskaDepartment of Molecular Microbiology, Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12/16, 90-237 Łódź, Poland.
Milena SęczkowskaDepartment of Organic and Applied Chemistry, Faculty of Chemistry, University of Lodz, Tamka 12, 91-403 Łódź, Poland.
Katarzyna Gach-JanczakDepartment of Biomolecular Chemistry, Medical University of Lodz, Mazowiecka 6/8, 92-215 Łódź, Poland.ORCID 0000-0002-3129-4158
Anita CiesielskaDepartment of Molecular Microbiology, Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12/16, 90-237 Łódź, Poland.ORCID 0000-0003-0172-0213
Paweł StączekDepartment of Molecular Microbiology, Faculty of Biology and Environmental Protection, University of Lodz, Banacha 12/16, 90-237 Łódź, Poland.ORCID 0000-0003-4416-8289
Marcin JasińskiDepartment of Organic and Applied Chemistry, Faculty of Chemistry, University of Lodz, Tamka 12, 91-403 Łódź, Poland.ORCID 0000-0002-8789-9690

Funding

Medical University of Lodz 503/1-156-02/503-11-001University of Łódź 19/IGB/2024University of Łódź 3/IDUB/DOS/2021
6 · The paper itself

Abstract

The emergence of antifungal resistance highlights the need for new chemotypes with improved biological activity. In this study, a series of new 3-CF

Indexed as

Antifungal AgentsDrug DesignHormesisTriazinesAnti-Bacterial AgentsCandida albicansHumansMicrobial Sensitivity TestsStructure-Activity RelationshipAnti-Bacterial AgentsAntifungal AgentsTriazines1,2,4-triazines(3+3)-cycloadditionsantimicrobial studyantimycoticscytotoxicity analysisfluoroorganicshormesisnitrile iminesselectivitysynthesis

Identifiers

PMID42589452
PMCPMC13466562

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.