Evidence map›Paper›PMID 42589440›Full record

ArticleInternational journal of molecular sciences2026

Elevated Estradiol and DHT Levels in the Prostatic Stroma as Key Drivers of Benign Prostatic Hyperplasia Pathogenesis.

Tomislav Pejčić, Milka Jadranin, Siniša Đurašević, Milica Kalaba, Biljana Dojčinović, Milica Zeković, Uroš Bumbaširević, Darko Jovanović, Darko Laketić, Živoslav Tešić and 1 more

Abstract read
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In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tomislav PejčićFaculty of Medicine, University of Belgrade, dr Subotića 8, 11000 Belgrade, Serbia.
Milka JadraninDepartment of Chemistry, University of Belgrade-Institute of Chemistry, Technology and Metallurgy, Njegoševa 12, 11158 Belgrade, Serbia.ORCID 0000-0002-4235-3504
Siniša ĐuraševićFaculty of Biology, University of Belgrade, Studentski trg 12-16, 11158 Belgrade, Serbia.ORCID 0000-0003-4406-8376
Milica KalabaInstitute of General and Physical Chemistry, Studentski trg 12-16, 11158 Belgrade, Serbia.ORCID 0000-0003-0989-7398
Biljana DojčinovićDepartment of Chemistry, University of Belgrade-Institute of Chemistry, Technology and Metallurgy, Njegoševa 12, 11158 Belgrade, Serbia.
Milica ZekovićCentre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Tadeuša Košćuška 1, 11000 Belgrade, Serbia.ORCID 0000-0003-2597-3426
Uroš BumbaširevićFaculty of Medicine, University of Belgrade, dr Subotića 8, 11000 Belgrade, Serbia.ORCID 0000-0003-0367-2745
Darko JovanovićClinic of Urology, University Clinical Center of Serbia, Pasterova 2, 11000 Belgrade, Serbia.ORCID 0009-0007-8935-7629
Darko LaketićFaculty of Medicine, University of Belgrade, dr Subotića 8, 11000 Belgrade, Serbia.ORCID 0000-0001-8228-8041
Živoslav TešićFaculty of Chemistry, University of Belgrade, Studentski trg 12-16, 11158 Belgrade, Serbia.ORCID 0000-0002-5162-3123
Tomislav TostiDepartment of Chemistry, University of Belgrade-Institute of Chemistry, Technology and Metallurgy, Njegoševa 12, 11158 Belgrade, Serbia.ORCID 0000-0002-1403-4688

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While dihydrotestosterone (DHT) has traditionally been considered the principal steroid in benign prostatic hyperplasia (BPH) pathogenesis, the role of estradiol (E2) and its relationship with local androgen accumulation remain unclear. This study investigated whether transition zone (TZ) tissue concentrations of E2, testosterone, and DHT are associated with prostate enlargement. TZ tissue cores were collected from 80 men undergoing prostate biopsy. Patients were stratified by total prostate volume (TPV): small (<30 mL) and enlarged (≥30 mL) prostate groups. Steroids were quantified using liquid chromatography-high resolution mass spectrometry. Tissue concentrations of E2, testosterone, and DHT were significantly higher in enlarged prostates (E2: 0.031 vs. 0.012 ng/g; testosterone: 0.804 vs. 0.517 ng/g; DHT: 7.903 vs. 3.526 ng/g; all

Indexed as

DihydrotestosteroneEstradiolProstateProstatic HyperplasiaAgedHumansMaleMiddle AgedStromal CellsTestosteroneDihydrotestosteroneEstradiolTestosteronebenign prostatic hyperplasiadihydrotestosteroneestradiolintraprostatic steroidsprostate enlargementtestosteronetransition zone

Identifiers

PMID42589440
PMCPMC13466709

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.