ArticleInternational journal of molecular sciences2026
Ghrelin Induces Clu
Fangming Zhang, Hui Jin, Gaifeng Ma, Asha Jacob, Ping Wang, Max Brenner
Abstract read
In one paragraphArticle in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
6 authors.
Fangming ZhangCenter for Immunology and Inflammation, The Feinstein Institutes for Medical Research, Manhasset, NY 11030, USA.
Hui JinCenter for Immunology and Inflammation, The Feinstein Institutes for Medical Research, Manhasset, NY 11030, USA.
Gaifeng MaCenter for Immunology and Inflammation, The Feinstein Institutes for Medical Research, Manhasset, NY 11030, USA.
Asha JacobCenter for Immunology and Inflammation, The Feinstein Institutes for Medical Research, Manhasset, NY 11030, USA.ORCID 0000-0002-8280-8999 Ping WangCenter for Immunology and Inflammation, The Feinstein Institutes for Medical Research, Manhasset, NY 11030, USA.ORCID 0000-0002-1557-0394 Max BrennerCenter for Immunology and Inflammation, The Feinstein Institutes for Medical Research, Manhasset, NY 11030, USA.ORCID 0000-0002-8010-148X Funding
Novel Approaches to Maintaining Organ Function in SepsisR35GM118337 · NIGMS · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI PING WANG · 2016 to 2026
$5.2MMechanisms of Radiation-Induced Innate Immune Dysfunction and Its CountermeasuresU01AI170018 · NIAID · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI Monowar Aziz, Max Brenner · 2022 to 2026
$4.2MGhrelin as Radiation Countermeasure: Mechanism of Its ActionU01AI186997 · NIAID · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI Max Brenner, Asha Varghese · 2025 to 2026
$1.2MMSP68 as an effective radiation countermeasureR21AI193493 · NIAID · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI Max Brenner, PING WANG · 2025 to 2026
$335kNational Institute of Allergy and Infectious Diseases R21AI193493National Institute of Allergy and Infectious Diseases U01AI170018National Institute of Allergy and Infectious Diseases U01AI186997NIAID NIH HHS R21 AI193493NIAID NIH HHS U01 AI170018NIAID NIH HHS U01 AI186997NIGMS NIH HHS R35 GM118337NIGMS NIH HHS R35GM118337
6 · The paper itselfAbstract
Gastrointestinal acute radiation syndrome (GI-ARS) is a deadly consequence of radiation exposure. We hypothesized that the peptide ghrelin is enteroprotective after radiation injury, and that ghrelin promotes intestinal stem cell regeneration via the vagus nerve. We subjected mice to 12-Gy partial body irradiation (PBI) with 5% bone marrow sparing. Some mice were vagotomized prior to PBI. We then injected the mice with human ghrelin (6 nmol/mouse) or vehicle at 24, 48, and 72 h post-irradiation, and collected blood and tissues at 96 h. PBI caused an 80% reduction in plasma citrulline, 32% shorter villi, 59% fewer crypts, a 14-fold increase in TUNEL
Indexed as
Acute Radiation SyndromeGhrelinReceptors, G-Protein-CoupledRegenerationStem CellsVagus NerveAnimalsHumansIntestinal MucosaMaleMiceGhrelinLgr5 protein, mouseReceptors, G-Protein-Coupledclusteringastrointestinal acute radiation syndromeghrelinintestinal stem cellsLgr5neuroenteric regulationpartial body irradiationradiation medical countermeasurevagus nerve
Identifiers
PMID42589437
PMCPMC13467369
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