Evidence map›Paper›PMID 42589376›Full record

ArticleInternational journal of molecular sciences2026

Progressive Metabolic Dysregulation from Prediabetes to Diabetes Revealed by Untargeted Metabolomics.

Maxat Toishimanov, Ivan Voitsekhovskiy, Aksholpan Shokan, Bakyt Kanapiyanov, Nurgul Myrzabayeva, Alma Nurtazina

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Maxat ToishimanovKazakhstan-Japan Innovative Center, Kazakh National Agrarian Research University, Almaty 050010, Kazakhstan.ORCID 0000-0002-6070-4574
Ivan VoitsekhovskiyFaculty of Biology and Biotechnology, Al-Farabi Kazakh National University, Almaty 050038, Kazakhstan.ORCID 0000-0001-6920-2776
Aksholpan ShokanInstitute of Genetic and Physiology, Almaty 050040, Kazakhstan.
Bakyt KanapiyanovDepartment of Propaedeutics of Internal Diseases, Semey Medical University, Semey 071400, Kazakhstan.
Nurgul MyrzabayevaKazakhstan-Japan Innovative Center, Kazakh National Agrarian Research University, Almaty 050010, Kazakhstan.
Alma NurtazinaDepartment of Epidemiology and Biostatistics, Semey Medical University, Semey 071400, Kazakhstan.ORCID 0009-0001-2904-6083

Funding

Ministry of Science and Higher Education of the Republic of Kazakhstan AP22686752
6 · The paper itself

Abstract

Type 2 diabetes (T2D) and prediabetes represent a progressive glycemic continuum associated with multi-pathway metabolic deterioration that often precedes clinical diagnosis. Early identification of molecular alterations underlying this transition is critical for prevention strategies. Untargeted gas chromatography-mass spectrometry (GC-MS) metabolomics combined with multivariate statistical analysis (PCA) was applied to serum samples from 188 participants stratified into Control (

Indexed as

Diabetes Mellitus, Type 2MetabolomeMetabolomicsPrediabetic StateAgedDisease ProgressionFemaleGas Chromatography-Mass SpectrometryHumansMaleMiddle Ageddiabetesmetabolic dysregulationmultivariate analysisprediabetesuntargeted metabolomics

Identifiers

PMID42589376
PMCPMC13466226

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.