Evidence map›Paper›PMID 42589366›Full record

ArticleInternational journal of molecular sciences2026

Non-Invasive Physical Plasma Regulates COX-2 via EP2/EP4 Expression in Periodontal Ligament Cells Under Inflammatory Conditions.

Benedikt Eggers, Rami Kharroubi, Jana Marciniak, Svenja Beisel-Memmert, James Deschner, Franz-Josef Kramer, Matthias Bernhard Stope, Marjan Nokhbehsaim

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Benedikt EggersDepartment of Oral, Maxillofacial and Plastic Surgery, University Hospital Bonn, 53111 Bonn, Germany.ORCID 0000-0002-4274-3801
Rami KharroubiSection of Experimental Dento-Maxillo-Facial Medicine, Center of Dento-Maxillo-Facial Medicine, University Hospital Bonn, Welschnonnenstrasse 17, 53111 Bonn, Germany.
Jana MarciniakSection of Experimental Dento-Maxillo-Facial Medicine, Center of Dento-Maxillo-Facial Medicine, University Hospital Bonn, Welschnonnenstrasse 17, 53111 Bonn, Germany.
Svenja Beisel-MemmertGoethe University Frankfurt, Carolinum, Department of Orthodontics, 60596 Frankfurt am Main, Germany.
James DeschnerDepartment of Periodontology and Operative Dentistry, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany.ORCID 0000-0001-8103-1885
Franz-Josef KramerDepartment of Oral, Maxillofacial and Plastic Surgery, University Hospital Bonn, 53111 Bonn, Germany.
Matthias Bernhard StopeDepartment of Gynecology and Gynecological Oncology, University Hospital Bonn, 53111 Bonn, Germany.
Marjan NokhbehsaimSection of Experimental Dento-Maxillo-Facial Medicine, Center of Dento-Maxillo-Facial Medicine, University Hospital Bonn, Welschnonnenstrasse 17, 53111 Bonn, Germany.ORCID 0000-0003-0998-1717

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periodontitis is a chronic inflammatory disease characterised by progressive destruction of the periodontal tissues and alveolar bone. Cyclooxygenase-2 (COX-2) plays a key role in the pathogenesis of inflammatory responses via prostaglandin E

Indexed as

Cyclooxygenase 2InflammationPeriodontal LigamentReceptors, Prostaglandin E, EP2 SubtypeReceptors, Prostaglandin E, EP4 SubtypeCells, CulturedGene Expression RegulationHumansInterleukin-1betaCyclooxygenase 2Interleukin-1betaPTGER2 protein, humanPTGER4 protein, humanPTGS2 protein, humanReceptors, Prostaglandin E, EP2 SubtypeReceptors, Prostaglandin E, EP4 SubtypeCOX-2hPDLCIL-1βnon-invasive physical plasma (NIPP)periodontitisPGE2 receptors

Identifiers

PMID42589366
PMCPMC13467514

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.